How do cross-reactive memory B cells affect influenza vaccine titers?

交叉反应记忆 B 细胞如何影响流感疫苗滴度？

• 批准号: nhmrc : 1103367
• 负责人: A/Pr Scott Boyd
• 金额: $ 55.07万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cross-reactive-memory-vaccine-titers/662674
• 关键词: How; do; cross; reactive; memory

Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.

流感疫苗经常更新，以预防高度可变的流感病毒。尽管对疫苗病毒进行了仔细的选择，但大多数流感疫苗只能提供适度的保护，而且有些年份的保护效果很差。反过来，对接种疫苗的反应因个人而异。这可能反映了流感感染和疫苗接种的复杂和多变的历史。该项目调查过去的流感暴露如何影响疫苗的反应和有效性。