How do signals cross the cell membrane: the betacommon receptor family

信号如何穿过细胞膜：β常见受体家族

• 批准号: DP220101788
• 负责人: Prof Michael Parker
• 金额: $ 43.24万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101788
• 关键词: How; do; signals; cross; cell

This project aims to unravel missing molecular details of how a family of proteins, called the betacommon receptors, is able to signal across cell walls. This project aims to generate new knowledge about how membrane-bound receptors transmit biological signals in living organisms. Despite their fundamental importance in biology, how these proteins work remain enigmatic. Expected outcomes include discovery of novel mechanisms general to these types of protein receptors and fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this new knowledge should benefit efforts to discover novel treatments in cases where malfunctioning receptors cause diseases in animals and humans.

该项目旨在解开一个名为β受体的蛋白质家族如何跨越细胞壁发出信号的缺失分子细节。该项目旨在产生关于膜结合受体如何在生物体中传递生物信号的新知识。尽管它们在生物学中具有根本的重要性，但这些蛋白质如何工作仍然是个谜。预期成果包括发现这些类型的蛋白质受体的新机制，以及了解所有生命王国的重要生理过程的基本见解。最终，这些新知识将有助于在受体功能障碍导致动物和人类疾病的情况下发现新的治疗方法。