How defects in centrosome to microtubule attachment cause microcephaly.

中心体与微管附着的缺陷如何导致小头畸形。

• 批准号: nhmrc : GNT1162652
• 金额: $ 58.08万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defects-centrosome-microtubule-cause-microcephaly/1379245
• 关键词: How; defects; centrosome; microtubule; attachment

Our project will define mechanisms in the developing brain responsible for a birth defect known as microcephaly, a condition characterized by reduced head size, cognitive capacity and epilepsy that severely impact the quality of life of affected individuals, their families and communities. We will reveal how errors in protein function and defects in neural stem cell divisions cause disease. This information will help us better understand how microcephaly develops for disease management.

我们的项目将定义发育中的大脑中负责称为小头畸形的出生缺陷的机制，这种情况的特征是头部尺寸减小，认知能力和癫痫，严重影响受影响个人，家庭和社区的生活质量。我们将揭示蛋白质功能的错误和神经干细胞分裂的缺陷如何导致疾病。这些信息将帮助我们更好地了解小头畸形如何发展为疾病管理。