CORE--RAPID CASE ASCERTAINMENT

快速确诊病例(确诊后两个月内确诊病例)对于成功开展高质量、以人群为基础的流行病学研究，特别是纳入分子生物学和生物标记物的病例对照研究至关重要。在安德鲁·奥尔山博士的指导下，快速病例确定(RCA)核心的目标是通过为北卡罗来纳州癌症病例的快速确定提供人员来支持基于人群的流行病学研究。RCA Core与北卡罗来纳州中央癌症登记处和调查人员合作，促进病例识别和数据收集，包括前往主要位于北卡罗来纳州中部和东部农村的较小、人手不足的医院并与其合作。RCA核心还通过协调项目IRB批准和参与HIPAA的合规性向研究人员提供咨询和行政援助 向医院和肿瘤登记机构提交报告；数据库开发；以及项目调查人员、北卡罗来纳州癌症登记中心和相关州委员会之间的活动。这一核心设施使在不同社区继续进行高质量、高成本效益的基于人群的研究成为可能。目前的四个巡回数据协调职位通过提供集中的协调确定，帮助减少了正在进行的研究的工作量，特别是为农村和服务不足的县的医院。在一次旅行中对多项研究进行病例查找，为研究提供了高度的效率和成本效益。2003年，来自两个项目的六名同行评审成员使用Core确定了9256例新病例，新病例包括#年乳腺癌、结直肠癌、前列腺癌、头颈部癌和卵巢癌 选定了8个县进行研究。北卡罗来纳州莱恩伯格大学的调查人员继续扩大他们在依赖于快速病例确定的基于人口的研究方面的努力。未来的计划包括在北卡罗来纳州开发一个专门用于RCA的安全网站。这将是一个有用的工具，为正在进行和即将进行的研究向医院癌症登记员和调查人员提供有价值的信息。

Rapid case ascertainment (case identification within two months after diagnosis) is critical to the successful conduct of quality, population-based, epidemiologic studies, particularly case-control studies that incorporate molecular biology and biomarkers. The goal of the Rapid Case Ascertainment (RCA) Core, under the direction of Dr. Andrew Olshan, is to support population-based epidemiology research by providing personnel for the rapid ascertainment of cancer cases in North Carolina. The RCA Core works with the NC Central Cancer Registry and investigators to facilitate case identification and data collection including traveling to and working with smaller, undermanned hospitals, located primarily in rural central and eastern North Carolina counties. The RCA Core also provides consultation and administrative assistance to researchers through the coordination of project IRB approvals and HIPAA compliance at participating hospitals; reports to hospitals and tumor registrars; database development; and activities among project investigators, the NC Central Cancer Registry, and related state committees. This Core Facility makes possible continued quality, cost-effective population-based research in diverse communities. The four current circuit-riding data coordination positions have helped reduce the workload from ongoing studies by providing centralized coordination ascertainment, especially for hospitals in rural and underserved counties. Case-finding takes place for multiple studies during a single trip, providing a high degree of efficiency and cost effectiveness for the studies. In 2003, six peer-reviewed members from two programs used the Core to identify 9,256 new cases new cases of breast, colorectal, prostate, head and neck, and ovarian cancer cases in selected counties for eight studies. UNC Lineberger investigators continue to expand their efforts in population-based studies that rely on rapid case ascertainment. Future plans include the development of a secure website dedicated to RCA in North Carolina. This will be a useful tool to provide valuable information to hospital cancer registrars and investigators for ongoing and upcoming research.