The North Carolina Center for Birth Defects Research and Prevention

北卡罗来纳州出生缺陷研究与预防中心

• 批准号: 8398908
• 负责人: ANDREW OLSHAN
• 金额: $ 56.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2014-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8398908
• 关键词: North; Carolina; Center; Birth; Defects

DESCRIPTION (provided by applicant): Birth defects continue to be a leading cause of infant mortality and childhood disability in the United States. The cause of most birth defects remains unknown. This overall objective of this proposal is to continue the activities of North Carolina Center for Birth Defects Research and Prevention (NCCBDRP). The NCCBDRP conducts research aimed at understanding the environmental and genetic causes of birth defects. The NCCBDRP oversees birth defects surveillance and participates in the National Birth Defects Prevention Study (NBDPS), a national case-control study of risk factors for birth defects. The overall goal of the NCCBDRP implementation of the NBDPS protocol is to identify and interview the mothers of 300 birth defects cases and 100 controls in our 33 county study area in North Carolina and collect buccal cell samples from the mother, father, and child for genetic analysis. The NCCBDRP will use pooled NBDPS data and DNA samples and in collaboration with other NBDPS centers proposes to investigate occupational, environmental, lifestyle and genetic factors in the etiology of birth defects. The NCCBDRP also proposes to use epidemiologic and statistical methods to evaluate the quality of the interview data and study design. Pilot studies will be conducted to expand and improve existing study design and methods. Although the NCCBDRP joined the NBDPS in only 2003, it has established a history of developing and implementing high quality case ascertainment and data collection systems, and a history of demonstrated collaborative research capacity. The NC Center has positively influenced the overall success of the NBDPS through its leadership and input on key study components.

描述（由申请人提供）：出生缺陷仍然是美国婴儿死亡和儿童残疾的主要原因。大多数出生缺陷的原因仍不清楚。该提案的总体目标是继续北卡罗来纳州出生缺陷研究和预防中心 (NCCBDRP) 的活动。 NCCBDRP 开展的研究旨在了解出生缺陷的环境和遗传原因。 NCCBDRP 负责监督出生缺陷监测并参与国家出生缺陷预防研究 (NBDPS)，这是一项针对出生缺陷危险因素的国家病例对照研究。 NCCBDRP 实施 NBDPS 协议的总体目标是识别并访谈北卡罗来纳州 33 个县研究区域中 300 名出生缺陷病例和 100 名对照者的母亲，并收集母亲、父亲和孩子的口腔细胞样本进行基因分析。 NCCBDRP 将使用汇总的 NBDPS 数据和 DNA 样本并与其他 NBDPS 中心合作，提议调查出生缺陷病因中的职业、环境、生活方式和遗传因素。 NCCBDRP 还建议使用流行病学和统计方法来评估访谈数据和研究设计的质量。将进行试点研究以扩大和改进现有的研究设计和方法。尽管 NCCBDRP 于 2003 年才加入 NBDPS，但它已经建立了开发和实施高质量病例查明和数据收集系统的历史，以及展示协作研究能力的历史。 NC 中心通过其对关键研究部分的领导和投入，对 NBDPS 的整体成功产生了积极影响。

项目成果

What we don't know can hurt us: Nonresponse bias assessment in birth defects research.

我们不知道的事情可能会伤害我们：出生缺陷研究中的无反应偏差评估。

• DOI: 10.1002/bdra.23408
• 发表时间: 2015
• 期刊: Birth defects research. Part A, Clinical and molecular teratology
• 作者: Strassle,PaulaD;Cassell,CynthiaH;Shapira,StuartK;Tinker,SarahC;Meyer,RobertE;Grosse,ScottD
• 通讯作者: Grosse,ScottD