CORE-- Developmental Susceptibility

描述(由申请人提供)：此核心的目的是促进合作 多学科研究计划，研究生命周期特定阶段的环境暴露如何影响疾病和发育缺陷的易感性。该计划的目标 发育易感性研究的核心是：促进和扩大关于在发育的脆弱阶段暴露的影响的合作研究，包括妊娠、出生缺陷、神经发育缺陷、儿童癌症和哮喘的不良结果；建立有效的机制，分享想法，讨论正在进行的研究，并促进将实验室、临床和流行病学方法整合到发育研究的新的跨学科项目；以及促进将分子和遗传标记纳入生殖和发育结果的传统流行病学研究。发展敏感性核心研究人员从事范围广泛的研究，从胚胎发育和出生缺陷机制的研究，到与怀孕、神经发育和儿童癌症的并发症和不良后果有关的环境和职业暴露的流行病学调查。

Description (provided by applicant): The purpose of this Core is to stimulate a collaborative multidisciplinary program of research on how environmental exposures at particular stages in the life cycle affect susceptibility to disease and to deficits in development. The objectives of the Developmental Susceptibility Research Core are to: foster and expand collaborative research on the effects of exposures during vulnerable stages in development, including adverse outcomes of pregnancy, birth defects, neurodevelopmental deficits, childhood cancer, and asthma; establish effective mechanisms for sharing ideas, discussing research in progress, and fostering new interdisciplinary ventures that integrate laboratory, clinical, and epidemiologic approaches to developmental studies; and promote incorporation of molecular and genetic markers into traditional epidemiology studies of reproductive and developmental outcomes. Developmental Susceptibility Core investigators are engaged in a broad spectrum of research ranging from studies of embryologic development and mechanisms of birth defects to epidemiologic investigations of environmental and occupational exposures in relation to complications and adverse outcomes of pregnancy, neurodevelopment, and childhood cancer.