Bone Geometry, Body Composition and Sex Hormones in Men

男性的骨骼几何形状、身体成分和性激素

• 批准号: 6923730
• 负责人: Lynn M. Marshall
• 金额: $ 15.1万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6923730
• 关键词: abdomen; adipose tissue; body composition; bone fracture; computed axial tomography; estradiol; hip; osteoporosis; pathologic process; spine; striated muscles; testosterone

DESCRIPTION (provided applicant): Osteoporosis is characterized by reduced bone strength that results in an increased risk of fracture, in the US, 1-2 million men ages 50 years or older are affected by osteoporosis. The contribution of reduced bone density to osteoporosis and fracture risk is well known. However, attention has turned toward bone geometry as another skeletal feature that may influence fracture risk. Bone geometry is determined by the relative amounts of tissue on the inner and outer bone surfaces. From a biomechanical perspective, bone strength is vitally dependent on geometry. The characteristics among older men that influence bone geometry and bone strength are virtually unknown. Bone growth and resorption are regulated through biologic pathways that involve mechanical loading from muscle forces, as well as non-mechanical factors such as endocrine effects. Therefore, we hypothesize that bone geometry in the hip and spine among older men will be associated with abdominal body composition and with endogenous levels of testosterone and estradiol. Abdominal muscles may directly affect mechanical loads on the hip and spine. Abdominal adipose tissues may affect overall loading patterns or may exert endocrine influences on bone. In older men, testosterone appears to stimulate bone growth and estradioi may inhibit bone loss. To test the hypothesized associations, we propose to use existing data from 1,800 US men ages 65 years and older who are participants in the Osteoporotic Fractures in Men (MrOS) cohort. Quantitative computed tomography (QCT) scans have been performed in this cohort. Bone geometry measures in the hip and spine and abdominal body composition measures are derived from these scans. Assays for testosterone and estradiol have also been performed for these participants. We will quantify the associations of bone geometry in the hip and spine with abdominal body composition, testosterone and estradiol using a cross-sectional design. The proposed project will yield new information about factors that influence bone geometry among older men.

描述（申请人提供）：骨质疏松症的特点是骨强度降低，导致骨折风险增加。在美国，1-200 万 50 岁或以上的男性患有骨质疏松症。骨密度降低对骨质疏松症和骨折风险的影响是众所周知的。然而，人们的注意力已经转向骨骼几何形状，作为可能影响骨折风险的另一个骨骼特征。骨骼的几何形状由骨骼内表面和外表面上组织的相对数量决定。从生物力学的角度来看，骨骼强度很大程度上取决于几何形状。老年男性中影响骨骼几何形状和骨骼强度的特征实际上尚不清楚。骨生长和吸收通过生物途径进行调节，涉及肌肉力量的机械负荷以及内分泌效应等非机械因素。因此，我们假设老年男性髋部和脊柱的骨骼几何形状与腹部身体成分以及睾酮和雌二醇的内源水平有关。腹部肌肉可能直接影响臀部和脊柱的机械负荷。腹部脂肪组织可能会影响整体负荷模式或可能对骨骼产生内分泌影响。在老年男性中，睾酮似乎会刺激骨骼生长，而雌二醇可能会抑制骨质流失。为了检验假设的关联，我们建议使用 1,800 名 65 岁及以上美国男性的现有数据，他们是男性骨质疏松性骨折 (MrOS) 队列的参与者。该队列已进行定量计算机断层扫描（QCT）扫描。髋部和脊柱的骨骼几何形状测量以及腹部身体成分测量均来自这些扫描。还对这些参与者进行了睾酮和雌二醇的检测。我们将使用横截面设计来量化臀部和脊柱的骨骼几何形状与腹部身体成分、睾酮和雌二醇的关联。拟议的项目将产生有关影响老年男性骨骼几何形状的因素的新信息。

项目成果

Comparison of Associations of DXA and CT Visceral Adipose Tissue Measures With Insulin Resistance, Lipid Levels, and Inflammatory Markers.

• DOI: 10.1016/j.jocd.2017.01.004
• 发表时间: 2017-04
• 期刊: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
• 作者: Schousboe JT;Langsetmo L;Schwartz AV;Taylor BC;Vo TN;Kats AM;Barrett-Connor E;Orwoll ES;Marshall LM;Miljkovic I;Lane NE;Ensrud KE;Osteoporotic Fractures in Men (MrOS) Study Research Group
• 通讯作者: Osteoporotic Fractures in Men (MrOS) Study Research Group