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Breast Cancer Survivorship: 10 Years Later

乳腺癌存活率：10 年后

基本信息

批准号：
6929016
负责人：
VICKI S HELGESON
金额：
$ 13.23万
依托单位：
CARNEGIE-MELLON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2007-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In 1993-1995, we enrolled 364 women with early stage breast cancer into a study, 312 of whom agreed to be randomized to a psychosocial group intervention: education, peer discussion, education + peer discussion, control. The education group had significant benefits to mental and physical functioning, some of which lasted 4 years. No benefits of peer discussion have been documented. In 1998, we began a case-control study of these women as they reached their 5-year survivorship mark. This study is notable for the rigorous control group employed (neighborhood controls) and the wide array of quality of life indices assessed. We found few differences in quality of life between cases and controls, consistent with other recent findings, with the exception of physical functioning. Survivors had worse functioning than controls. We would like to conduct one final in-person interview with these women as they reach their 10-year survivorship mark. Research on survivorship is lacking in general, and there is very little research on 10-year survivors. The goals of the study are: (1) to investigate the positive aspects of the cancer experience with a series of open-ended and close-ended questions on benefit-finding; (2) to describe how survivorship is integrated into women's self-concepts and examine the implications of the survivor self-concept for quality of life; (3) to evaluate changes in quality of life over the 10 years and to discriminate women who are adjusting well in the long-term from those who are having continued difficulties, and (4) to evaluate the research study, including the intervention. We wilt conduct in-person interviews with survivors and significant others to address the issues of benefit-finding and survivor self-concept. We will measure quality of life broadly, identify trajectories of quality of life over the 10 years, and discriminate among the different patterns of change. Finally, we will conduct focus groups with women to examine the positive and negative aspects of their experience with the research study.

描述（由申请人提供）：1993-1995 年，我们招募了 364 名患有早期乳腺癌的女性参加一项研究，其中 312 名同意随机接受社会心理小组干预：教育、同伴讨论、教育 + 同伴讨论、对照。教育组对精神和身体机能有显着的好处，其中一些效果持续了 4 年。同行讨论的好处尚未被记录。 1998 年，当这些女性达到 5 年生存期时，我们开始对她们进行病例对照研究。这项研究的值得注意之处在于采用了严格的对照组（邻里对照）和评估的广泛的生活质量指数。我们发现病例和对照之间的生活质量几乎没有差异，这与其他最近的发现一致，除了身体功能之外。幸存者的功能比对照组更差。当这些女性的生存期达到 10 年时，我们希望对她们进行最后一次面对面采访。对幸存者的研究普遍缺乏，对10年幸存者的研究也很少。该研究的目标是：（1）通过一系列关于获益的开放式和封闭式问题来调查癌症经历的积极方面； (2) 描述如何将幸存者纳入妇女的自我概念，并研究幸存者自我概念对生活质量的影响； (3) 评估 10 年来生活质量的变化，并将长期适应良好的女性与持续困难的女性区分开来，以及 (4) 评估研究，包括干预措施。我们将与幸存者和其他重要人士进行面对面访谈，以解决寻求利益和幸存者自我概念的问题。我们将广泛衡量生活质量，确定十年来生活质量的轨迹，并区分不同的变化模式。最后，我们将与女性进行焦点小组讨论，以检查她们在研究中的经历的积极和消极方面。