Breast Cancer Survivorship: 10 Years Later

乳腺癌存活率：10 年后

• 批准号: 6819639
• 负责人: VICKI S HELGESON
• 金额: $ 13.15万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6819639
• 关键词: attitude; behavioral /social science research tag; breast neoplasms; clinical research; female; functional ability; health behavior; health care service evaluation; human subject; human therapy evaluation; interpersonal relations; interview; long term survivor; longitudinal human study; neoplasm /cancer education; outcomes research; peer group; psychometrics; quality of life; questionnaires; self concept; women' s health

DESCRIPTION (provided by applicant): In 1993-1995, we enrolled 364 women with early stage breast cancer into a study, 312 of whom agreed to be randomized to a psychosocial group intervention: education, peer discussion, education + peer discussion, control. The education group had significant benefits to mental and physical functioning, some of which lasted 4 years. No benefits of peer discussion have been documented. In 1998, we began a case-control study of these women as they reached their 5-year survivorship mark. This study is notable for the rigorous control group employed (neighborhood controls) and the wide array of quality of life indices assessed. We found few differences in quality of life between cases and controls, consistent with other recent findings, with the exception of physical functioning. Survivors had worse functioning than controls. We would like to conduct one final in-person interview with these women as they reach their 10-year survivorship mark. Research on survivorship is lacking in general, and there is very little research on 10-year survivors. The goals of the study are: (1) to investigate the positive aspects of the cancer experience with a series of open-ended and close-ended questions on benefit-finding; (2) to describe how survivorship is integrated into women's self-concepts and examine the implications of the survivor self-concept for quality of life; (3) to evaluate changes in quality of life over the 10 years and to discriminate women who are adjusting well in the long-term from those who are having continued difficulties, and (4) to evaluate the research study, including the intervention. We wilt conduct in-person interviews with survivors and significant others to address the issues of benefit-finding and survivor self-concept. We will measure quality of life broadly, identify trajectories of quality of life over the 10 years, and discriminate among the different patterns of change. Finally, we will conduct focus groups with women to examine the positive and negative aspects of their experience with the research study.

描述（由申请人提供）：1993-1995年，我们招募了364名早期乳腺癌妇女参加一项研究，其中312人同意随机分配到心理社会小组干预：教育，同伴讨论，教育+同伴讨论，对照。受教育组对心理和身体功能有显着的益处，其中一些持续了4年。同行讨论的好处没有记录在案。1998年，我们开始对这些妇女进行病例对照研究，因为她们达到了5年生存期。这项研究是值得注意的严格控制组（邻里控制）和广泛的生活质量指数评估。我们发现，除了身体功能外，病例组和对照组之间的生活质量几乎没有差异，这与最近的其他研究结果一致。幸存者的功能比对照组更差。我们想对这些女性进行最后一次面对面的采访，因为她们已经达到了10年的生存期。一般来说，对生存率的研究很少，对10年生存率的研究也很少。本研究的目的是：（1）通过一系列关于受益发现的开放式和封闭式问题来调查癌症经历的积极方面;（2）描述生存是如何融入妇女的自我概念的，并检查幸存者自我概念对生活质量的影响;（3）评估10年来生活质量的变化，区分长期适应良好的妇女和持续存在困难的妇女，（4）评估研究，包括干预措施。我们将与幸存者和重要的其他人进行面对面的访谈，以解决利益发现和幸存者自我概念的问题。我们将广泛地衡量生活质量，确定10年来生活质量的轨迹，并区分不同的变化模式。最后，我们将与妇女进行焦点小组讨论，以检查他们在研究中的积极和消极方面的经验。