Functional Connectivity During Working Memory Maintenance

工作记忆维护期间的功能连接

• 批准号: 7000192
• 负责人: Jesse A Rissman
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000192
• 关键词: behavioral /social science research tag; clinical research; cognition; evoked potentials; functional magnetic resonance imaging; human subject; neuropsychology; predoctoral investigator; short term memory; statistics /biometry

DESCRIPTION (provided by applicant): The long-term objective of this research plan is to further our understanding of the neural basis of working memory (WM). Specifically, the goals of this proposal are to characterize the network of functionally connected brain regions mediating visual WM maintenance and determine the behavioral significance of their interactions. Many theories of visual WM postulate the prefrontal cortex (PFC) provides top-down signals to posterior visual association areas in order to keep behaviorally relevant perceptual information activated when it is no longer accessible in the environment. However, evidence for the existence of this interaction is limited and indirect. The experiments outlined in this proposal will use event-related functional magnetic resonance imaging to measure activity levels throughout the brain as subjects perform WM tasks. A recently developed multivariate analysis procedure will then be applied to the data to examine inter-regional interactions during the component stages of WM. The first experiment will seek to determine whether the strength and nature of these interactions is related to behavioral performance. The second and third experiments will assess the mechanisms by which the WM system can dynamically adapt its functional connectivity profile to accommodate increased memory load or overcome distraction.

描述（由申请人提供）：本研究计划的长期目标是进一步了解工作记忆（WM）的神经基础。具体而言，本提案的目标是表征调节视觉WM维持的功能连接脑区域网络，并确定其相互作用的行为意义。许多视觉WM理论假设前额叶皮层（PFC）向后视关联区提供自上而下的信号，以便在环境中无法获得行为相关的感知信息时保持激活状态。然而，这种相互作用存在的证据是有限的和间接的。本提案中概述的实验将使用与事件相关的功能性磁共振成像来测量受试者执行WM任务时整个大脑的活动水平。然后将对数据应用最近开发的多变量分析程序，以检查WM组成阶段的区域间相互作用。第一个实验将试图确定这些相互作用的强度和性质是否与行为表现有关。第二个和第三个实验将评估WM系统动态调整其功能连接概况以适应增加的记忆负荷或克服分心的机制。