Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center

MACS/WIHS 联合队列研究 (MACS/WIHS-CCS) 的临床研究中心 - 巴尔的摩/华盛顿特区中心

• 批准号: 10370339
• 负责人: TODD T BROWN
• 金额: $ 408.12万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370339
• 关键词: Achievement; Acquired Immunodeficiency Syndrome; Affect; Age; Aging; Ancillary Study; Area; Artificial Intelligence; Baltimore; Behavioral; Biological; Biological Specimen Banks; Cardiovascular Diseases; Cardiovascular system; Caring; Chicago; Chronic Disease; Clinic; Cohort Studies; Cryopreservation; Data; Data Coordinating Center; Diabetes Mellitus; Disease; District of Columbia; Echocardiography; Endocrine; Enrollment; Epidemic; Equilibrium; Event; Follow-Up Studies; Funding; Goals; Grant; HIV; HIV Infections; HIV antiretroviral; Health; Health behavior; Home; Hospitals; Impaired cognition; Inflammation; Laboratories; Lead; Leadership; Liver diseases; Long-Term Care; Los Angeles; Lung; Machine Learning; Malignant Neoplasms; Measurement; Medicine; Metabolic; Metabolic Diseases; Methods; National Heart, Lung, and Blood Institute; Natural History; Neurocognitive; Participant; Pathogenesis; Performance; Peripheral Blood Mononuclear Cell; Persons; Physical activity; Plasma; Play; Polysomnography; Principal Investigator; Protocols documentation; Publications; Questionnaires; RNA; Reading; Recording of previous events; Research; Research Personnel; Risk Factors; Role; Science; Site; Sleep; Specimen; T-Lymphocyte Subsets; Techniques; The Multicenter AIDS Cohort Study; Time; Viral load measurement; Walkers; Washington; Woman; Women' s Interagency HIV Study; Work; actigraphy; adjudication; antiretroviral therapy; base; career development; clinical care; clinical research site; cohort; comorbidity; data management; experience; follow-up; health disparity; high standard; improved; innovation; men; men who have sex with men; men' s group; neurocognitive disorder; psychosocial; recruit; repository; research study; response; synergism

Project Summary This application is for the renewal of the Study to Help the AIDS Research Effort (SHARE), which has been the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) since 1984. The MACS was established with sites in Baltimore-Washington, Chicago, Pittsburgh, and Los Angeles, initially to study the natural history of HIV infection in men who have sex with men and later, with the advent of effective combination antiretroviral therapy (cART), the treated history of HIV infection, including the relationship between long-term controlled HIV infection and chronic diseases and co-morbidities associated with aging. To reflect these changing priorities in HIV research, SHARE has had subsequent enrollments to balance proportions of HIV- and HIV+ men and to reflect the HIV epidemic more accurately. Men enrolled have been followed semi annually since 1984 or enrollment and have a) provided questionnaire data, physical exam data, laboratory data (including HIV serostatus, T cell subset measurements, and HIV viral load measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells, and other specimens; and these have permitted SHARE and MACS to make major contributions to the understanding of treated and untreated HIV disease, and comorbidities associated with increased survival due to antiretroviral treatment. The present application, in response to RFA-HL-19-008, aims to extend followup of the SHARE cohort (about 640 men) from 2019 to 2026, to allow merger of SHARE (and the other MACS sites) with the nine sites of the Women’s Interagency HIV Study (WIHS) into a single cohort, termed the MACS-WIHS Combined Cohort Study (CCS), that will include both men and women. The specific aims of the CCS are outlined in a parallel application from the putative Data and Coordinating Center (DACC) of the CCS, and the 10 Specific Aims of that single cohort are outlined in the DACC application for the CCS; these include Cardiovascular (CV), Pulmonary/Sleep (PS), Neurocognitive NC), Aging (AG), Cancer, HIV Pathogenesis (PA), Psychosocial (PS), Health Disparities, Platform (PL), and Career Development (CD) Aims. The specific aims of the SHARE Clinical Research Site (CRS) are to: 1) play a leading role in the achievement 7 of these Aims by the CCS (i.e., CV, PS, AG, PA, PS, PL, and CD), including serving as a reading center for echocardiography and sleep studies; 2) to contribute to the achievement of the other 3 CCS aims, and 3) to implement all applicable CCS protocols and support the scientific goals of the CCS. Local initiatives on inflammation and physical activity will also support these aims, which take full advantage of the extensive follow-up and repository of biological specimens already available from this cohort and which will be extended under this proposal, enabling further contributions to our understanding and care of comorbidities and other health issues faced by people living with HIV today.

项目摘要 此申请是为了更新“帮助艾滋病研究工作的研究”（SHARE），该研究已 自1984年以来一直是多中心艾滋病队列研究（MACS）的巴尔的摩-华盛顿特区网站。互委会 在巴尔的摩-华盛顿、芝加哥、匹兹堡和洛杉矶建立了研究中心，最初是为了研究 男男性行为者与艾滋病病毒感染者自然史相结合后， 抗逆转录病毒治疗（cART）、艾滋病毒感染的治疗史，包括长期之间的关系 控制艾滋病毒感染和慢性病以及与衰老相关的合并症。以反映这些 改变艾滋病毒研究的优先事项，SHARE随后进行了登记，以平衡艾滋病毒的比例， 艾滋病毒阳性男子，并更准确地反映艾滋病毒的流行。每半年对入组的男性进行随访 自1984年或入组以来，并已a）提供问卷数据、体检数据、实验室数据（包括 HIV血清状态、T细胞亚群测量和HIV病毒载量测量），以及大量的HIV抗体库。 血浆、血清、冷冻保存的外周血单核细胞和其他样本;这些样本具有 允许SHARE和MACS为理解治疗和未治疗的艾滋病毒做出重大贡献 疾病，以及与抗逆转录病毒治疗增加生存率相关的合并症。 本申请是对RFA-HL-19-008的回应，旨在延长SHARE队列的随访 （约640名男子），以允许SHARE（和其他MACS站点）与九个站点合并 将妇女机构间艾滋病毒研究（WIHS）纳入一个队列，称为MACS-WIHS联合队列 研究（CCS），将包括男性和女性。综合传播战略的具体目标也同时概述， 从CCS的假定数据和协调中心（DACC）的应用，以及10个具体目标， 在CCS的DACC应用程序中概述了单个队列;这些队列包括心血管（CV）， 肺/睡眠（PS）、神经认知（NC）、衰老（AG）、癌症、HIV发病机制（PA）、心理社会（PS）， 健康差异，平台（PL）和职业发展（CD）目标。SHARE Clinical的具体目标 研究中心（CRS）将：1）在CCS实现这些目标的过程中发挥主导作用（即，CV、PS、 AG、PA、PS、PL和CD），包括充当超声心动图和睡眠研究的阅读中心; 2） 有助于实现其他3个CCS目标，以及3）执行所有适用的CCS议定书， 支持CCS的科学目标。当地关于炎症和身体活动的倡议也将支持 这些目标充分利用了广泛的后续行动和生物标本储存库， 可从这一组，并将根据本建议扩大，使我们的进一步贡献， 了解和关心艾滋病毒感染者今天面临的合并症和其他健康问题。