Cognition and MRI in Adolescent Cannabis Users

青少年大麻使用者的认知和 MRI

• 批准号: 6993063
• 负责人: Krista Maurine Lisdahl
• 金额: $ 4.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993063
• 关键词: Cannabis; adolescence (12-20); attention; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; cerebellum; clinical research; cognition; drug detection; executive function; gender difference; human subject; magnetic resonance imaging; marijuana abuse; memory; neuropsychological tests; postdoctoral investigator; prefrontal lobe /cortex; psychomotor reaction time; psychopharmacology; questionnaires

DESCRIPTION (provided by applicant): Cannabis is the most widely used illicit substance among adolescents; however, the long-term neural consequences of chronic use are relatively understudied. The effects of cannabis on brain structure have yielded inconsistent results, as some have found differences in brain volume and others have not. Studies examining the cognitive effects of chronic cannabis use have primarily demonstrated subtle deficits in memory and attention. Of concern is that the current literature lacks studies that adequately assess the effects of cannabis exposure in adolescents during the critical period of neuromaturation. Therefore, the goal of this project is to examine whether cannabis use during late adolescence is associated with long-lasting brain structural changes, measured by magnetic resonance imaging (MRI), and neuropsychological functioning. Gender will also be explored as a potential moderator variable between brain structure, neuropsychological functioning, and cannabis use. Data will be collected from two groups of 16-18 year old adolescents: 1) Cannabis users and 2) Non-drug using controls who have verified 28-days of abstinence. Based on animal models and existing data in humans, it is hypothesized that cannabis use will be associated with decreased brain volume in prefrontal and cerebellar regions and poorer cognitive performance on tests of learning and memory, working memory, attention, executive functioning, and psychomotor speed.

描述（由申请人提供）： 大麻是青少年中最广泛使用的非法物质。但是，长期使用的长期神经后果相对研究。大麻对大脑结构的影响产生了不一致的结果，因为有些人发现大脑体积差异，而另一些则没有。研究了慢性大麻使用的认知作用的研究主要证明了记忆和注意力的细微缺陷。令人担忧的是，目前的文献缺乏研究在神经饱和的关键时期充分评估青少年大麻暴露的影响。因此，该项目的目的是检查青春期晚期的大麻使用是否与持续的大脑结构变化有关，该变化是通过磁共振成像（MRI）和神经心理学功能衡量的。性别也将作为大脑结构，神经心理功能和大麻使用之间的潜在主持人变量探索。数据将从两组16-18岁的青少年组中收集：1）大麻用户和2）使用已验证28天禁欲的控件的非药物。基于动物模型和人类的现有数据，假设使用大麻将与前额叶和小脑区域的大脑体积减少有关，以及在学习和记忆，工作记忆，工作记忆，注意力，执行功能和心理驱动器速度的测试中的认知性能较差。