Cognition and MRI in Adolescent Cannabis Users

青少年大麻使用者的认知和 MRI

• 批准号: 7117264
• 负责人: Krista Maurine Lisdahl
• 金额: $ 4.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2007-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7117264
• 关键词: Cannabis; adolescence (12-20); attention; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; cerebellum; clinical research; cognition; drug detection; executive function; gender difference; human subject; magnetic resonance imaging; marijuana abuse; memory; neuropsychological tests; postdoctoral investigator; prefrontal lobe /cortex; psychomotor reaction time; psychopharmacology; questionnaires

DESCRIPTION (provided by applicant): Cannabis is the most widely used illicit substance among adolescents; however, the long-term neural consequences of chronic use are relatively understudied. The effects of cannabis on brain structure have yielded inconsistent results, as some have found differences in brain volume and others have not. Studies examining the cognitive effects of chronic cannabis use have primarily demonstrated subtle deficits in memory and attention. Of concern is that the current literature lacks studies that adequately assess the effects of cannabis exposure in adolescents during the critical period of neuromaturation. Therefore, the goal of this project is to examine whether cannabis use during late adolescence is associated with long-lasting brain structural changes, measured by magnetic resonance imaging (MRI), and neuropsychological functioning. Gender will also be explored as a potential moderator variable between brain structure, neuropsychological functioning, and cannabis use. Data will be collected from two groups of 16-18 year old adolescents: 1) Cannabis users and 2) Non-drug using controls who have verified 28-days of abstinence. Based on animal models and existing data in humans, it is hypothesized that cannabis use will be associated with decreased brain volume in prefrontal and cerebellar regions and poorer cognitive performance on tests of learning and memory, working memory, attention, executive functioning, and psychomotor speed.

描述(由申请人提供)： 大麻是青少年中使用最广泛的非法物质；然而，长期使用大麻对神经的影响研究相对较少。大麻对大脑结构的影响产生了不一致的结果，因为一些人发现了大脑体积的差异，而另一些人没有。对长期使用大麻对认知影响的研究初步表明，记忆和注意力存在细微的缺陷。令人担忧的是，目前的文献缺乏充分评估在神经成熟关键时期暴露于大麻对青少年的影响的研究。因此，该项目的目标是检查青春期后期使用大麻是否与磁共振成像(MRI)测量的长期脑结构变化和神经心理功能有关。还将探索性别作为大脑结构、神经心理功能和大麻使用之间的潜在调节变量。数据将从两组16-18岁的青少年中收集：1)吸食大麻的人和2)非吸食毒品的对照组，他们已经验证了28天的戒毒。根据动物模型和现有的人类数据，假设大麻的使用将与前额叶和小脑区域的大脑体积减少以及在学习和记忆、工作记忆、注意力、执行功能和精神运动速度测试中的认知表现较差有关。