Neurobehavioral Features of FASD and ADHD

FASD 和 ADHD 的神经行为特征

• 批准号: 6938299
• 负责人: MATTHEW J BURDEN
• 金额: $ 4.92万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6938299
• 关键词: African American; adolescence (12-20); attention; attention deficit disorder; behavioral /social science research tag; child psychology; clinical research; executive function; fetal alcohol syndrome; functional ability; human subject; interview; longitudinal human study; mathematical ability; mathematical model; mental disorder diagnosis; neuropsychological tests; neuropsychology; postdoctoral investigator; short term memory

DESCRIPTION (provided by applicant): The goal of this research is to characterize the neurobehavioral features of fetal alcohol spectrum disorder (FASD) and attention deficit hyperactivity disorder (ADHD). Because children with these disorders often present with similar deficits in attention, memory, learning, and behavior, the extent to which they possess distinct neurobehavioral features is unclear. The proposed study will examine adolescents from the Detroit Longitudinal Alcohol cohort, whose mothers were recruited prospectively during pregnancy to over represent moderate-to-heavy levels of prenatal alcohol exposure; a high proportion of this cohort is also suspect for ADHD. Adolescents will be invited to participate in a 16- to 18-year follow-up assessment based on membership in one of the following groups: 1) FASD; 2) ADHD; 3) FASD and ADHD; and 4) neither disorder. The primary focus will be concerned with specific outcomes within the domains of executive function and arithmetic that are most likely to distinguish between these groups. Growth curve modeling will be used to examine developmental trajectories within these domains at 7.5-, 14-, and 16-18 years. This research will generate new information regarding the neurobehavioral characteristics of each disorder, thus providing new insights for educational, clinical, and pharmacological interventions. The potential health hazards associated with treating FASD with psycho stimulants in the same manner as ADHD underscore the importance for understanding distinctive features that can improve the differential diagnoses of these disorders.

描述（由申请人提供）：这项研究的目的是表征胎儿酒精谱系障碍（FASD）和注意力不足多动障碍（ADHD）的神经行为特征。由于这些疾病的儿童通常在注意力，记忆，学习和行为上存在类似的缺陷，因此他们拥有独特的神经行为特征的程度尚不清楚。 拟议的研究将检查来自底特律纵向酒精队列的青少年，他们的母亲在怀孕期间被预期招募，以代表中度至重度的产前酒精暴露；该队列中的很大一部分也被怀疑多动症。将邀请青少年根据以下一个组之一的成员资格参加16至18年的随访评估：1）FASD； 2）多动症； 3）FASD和ADHD； 4）既不是疾病。主要重点将关注执行功能和算术领域内最有可能区分这些组的特定结果。生长曲线建模将用于检查7.5，14年和16 - 18年的这些领域内的发展轨迹。这项研究将产生有关每种疾病的神经行为特征的新信息，从而为教育，临床和药理干预提供新的见解。与心理兴奋剂治疗FASD相关的潜在健康危害与ADHD相同的方式强调了可以改善这些疾病的差异诊断的独特特征的重要性。