Long-term Maternal Effects on Developing Offspring

母体对后代发育的长期影响

• 批准号: 6919387
• 负责人: ROSEMARY STRASSER
• 金额: $ 7.05万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6919387
• 关键词: androgen inhibitor; animal developmental psychology; behavior test; behavioral /social science research tag; biological models; chick embryo; corticosterone; developmental disease /disorder; dihydrotestosterone; early experience; embryo /fetus; ethology; feces analysis; gender difference; hormone sensitivity /resistance; juvenile animal; longitudinal animal study; maternal behavior; mature animal; paternal behavior; postnatal growth disorder; reproduction; sex behavior; songbirds; territoriality; testosterone

DESCRIPTION (provided by applicant): Vertebrate mothers deposit variable amounts of maternal steroid hormones in their eggs. Early exposure to steroids, whether endogenous or exogenous, may have long-lasting effects on the development and survival of an organism. In avian species, the concentration of these steroids, mostly androgens, found in the egg yolks vary within and among clutches. The possibility of organizational actions of these naturally occurring doses of maternal androgens, analogous to that regulating development of sexually dimorphic traits and behavior, remains largely unexplored. Because the offspring develop outside the mother, birds provide an excellent model system in which to manipulate and examine maternal hormonal effects without potential feedback effects derived from maternal endocrine physiology. The avian model of early hormone effects thus represents a very promising alternative system to the well-established mammalian model. It is the specific goal of the following proposed study to provide information regarding long-term maternal hormone effects on offspring development including potential transgenerational effects. Using an experimental design, exposure to testosterone and anti-androgens during development will be manipulated in order to examine the effects on morphology, physiology, and behavior of juvenile and adult offspring. New information will be obtained regarding 1) the effects of prenatal testosterone and anti-androgen treatment on offspring growth and development; 2) the organizational effects of testosterone and antiandrogens on offspring reproduction and parental behavior; and 3) the plasticity of maternal hormonal effects on subsequent generations. Results from these studies will contribute to our knowledge of how early hormone exposure (or absence) influence and organize the brain for later occurring activational events. With the growing popularity of hormonal treatments in various clinical populations and the prevalence of environmental anti-androgens, it is critical to not only understand how early hormonal histories influences an individual's current physiology and behavior but also how it might influence the phenotype of their future offspring via transgenerational maternal effects.

描述（由申请人提供）：脊椎动物母亲在其卵中存款不同量的母体类固醇激素。早期接触类固醇，无论是内源性还是外源性的，都可能对生物体的发育和生存产生长期影响。在鸟类中，蛋黄中发现的这些类固醇（主要是雄激素）的浓度在窝内和窝间各不相同。这些自然发生的剂量的母体雄激素的组织行动的可能性，类似于调节性二态性状和行为的发展，仍然在很大程度上未被探索。由于后代在母体外发育，鸟类提供了一个很好的模型系统，在其中操纵和检查母体激素效应，而没有来自母体内分泌生理学的潜在反馈效应。因此，早期激素效应的禽类模型代表了一个非常有前途的替代系统，以完善的哺乳动物模型。 以下拟议研究的具体目标是提供关于母体激素对后代发育的长期影响（包括潜在的跨代影响）的信息。使用实验设计，将操纵发育期间暴露于睾酮和抗雄激素，以检查对幼龄和成年后代形态、生理和行为的影响。 将获得以下新信息：1）产前睾酮和抗雄激素治疗对后代生长发育的影响; 2）睾酮和抗雄激素对后代生殖和父母行为的组织影响; 3）母体激素对后代影响的可塑性。这些研究的结果将有助于我们了解早期激素暴露（或缺乏）如何影响和组织大脑，以应对随后发生的激活事件。随着激素治疗在各种临床人群中的日益普及以及环境抗雄激素的流行，不仅要了解早期激素史如何影响个体当前的生理和行为，而且还要了解它如何通过跨代母体效应影响其未来后代的表型。