Long-term Maternal Effects on Developing Offspring

母体对后代发育的长期影响

• 批准号: 7047775
• 负责人: ROSEMARY STRASSER
• 金额: $ 6.88万
• 依托单位: UNIVERSITY OF NEBRASKA OMAHA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047775
• 关键词: androgen inhibitor; animal developmental psychology; behavior test; behavioral /social science research tag; biological models; chick embryo; corticosterone; developmental disease /disorder; dihydrotestosterone; early experience; embryo /fetus; ethology; feces analysis; gender difference; hormone sensitivity /resistance; juvenile animal; longitudinal animal study; maternal behavior; mature animal; paternal behavior; postnatal growth disorder; reproduction; sex behavior; songbirds; territoriality; testosterone

DESCRIPTION (provided by applicant): Vertebrate mothers deposit variable amounts of maternal steroid hormones in their eggs. Early exposure to steroids, whether endogenous or exogenous, may have long-lasting effects on the development and survival of an organism. In avian species, the concentration of these steroids, mostly androgens, found in the egg yolks vary within and among clutches. The possibility of organizational actions of these naturally occurring doses of maternal androgens, analogous to that regulating development of sexually dimorphic traits and behavior, remains largely unexplored. Because the offspring develop outside the mother, birds provide an excellent model system in which to manipulate and examine maternal hormonal effects without potential feedback effects derived from maternal endocrine physiology. The avian model of early hormone effects thus represents a very promising alternative system to the well-established mammalian model. It is the specific goal of the following proposed study to provide information regarding long-term maternal hormone effects on offspring development including potential transgenerational effects. Using an experimental design, exposure to testosterone and anti-androgens during development will be manipulated in order to examine the effects on morphology, physiology, and behavior of juvenile and adult offspring. New information will be obtained regarding 1) the effects of prenatal testosterone and anti-androgen treatment on offspring growth and development; 2) the organizational effects of testosterone and antiandrogens on offspring reproduction and parental behavior; and 3) the plasticity of maternal hormonal effects on subsequent generations. Results from these studies will contribute to our knowledge of how early hormone exposure (or absence) influence and organize the brain for later occurring activational events. With the growing popularity of hormonal treatments in various clinical populations and the prevalence of environmental anti-androgens, it is critical to not only understand how early hormonal histories influences an individual's current physiology and behavior but also how it might influence the phenotype of their future offspring via transgenerational maternal effects.

描述（由申请人提供）：脊椎动物母亲在其卵中沉积不同数量的母体类固醇激素。早期暴露于类固醇，无论是内源性还是外源性，都可能对生物体的发育和生存产生长期影响。在鸟类中，蛋黄中这些类固醇（主要是雄激素）的浓度在窝内和窝中各不相同。这些自然发生的雌性雄激素剂量的组织作用的可能性，类似于调节两性二态特征和行为的发展，在很大程度上仍未被探索。由于后代在母体外发育，鸟类提供了一个很好的模型系统，可以在没有母体内分泌生理学潜在反馈效应的情况下操纵和检查母体激素的影响。因此，早期激素效应的鸟类模型代表了一个非常有前途的替代系统，以完善的哺乳动物模型。