EFFECTIVE CONNECTIVITY IN BRAIN IMAGING OF VISION

大脑视觉成像中的有效连接

• 批准号: 6927803
• 负责人: Robert Randolph Blake
• 金额: $ 15.1万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6927803
• 关键词: binocular vision; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; functional magnetic resonance imaging; human subject; mathematical model; model design /development; neural information processing; technology /technique development; visual perception

DESCRIPTION (provided by applicant): This proposal, submitted under the auspices of the program supporting Small Grants for Pilot Research, seeks funds to develop, refine and validate analytic techniques for inferring the relative contributions of feedforward and feedback contributions to fMRI activations in multiple visual areas. Specifically, we will use nonlinear equations to model activations (blood oxygen-level dependent signals registered using functional magnetic resonance imaging) measured while human observers report fluctuations in visual perception associated with viewing binocular rivalry (i.e., the alternations in visual awareness between two dissimilar images viewed by the separate eyes). These analytic techniques have been described in the literature (Buchel & Friston, 1995) but have been rarely employed in studies of vision, despite their potential for significantly extending the range of conclusions drawn from brain imaging studies. Given the dramatic increase in the use of fMRI for the study of vision and its disorders, it is imperative to develop, refine and validate techniques that extend the range of problems that can be addressed using fMRI. The present proposal has this potential.

描述（由申请人提供）：本提案是在支持试点研究小额赠款项目的主持下提交的，旨在寻求资金来开发、改进和验证分析技术，以推断前馈和反馈对多个视觉区域功能磁共振成像激活的相对贡献。具体地说，我们将使用非线性方程来模拟激活（使用功能性磁共振成像记录的血氧水平依赖信号），同时人类观察者报告与观察双眼竞争相关的视觉感知波动（即，由不同的眼睛看到的两个不同图像之间的视觉感知的交替）。这些分析技术已在文献中描述（Buchel & Friston，1995），但很少用于视觉研究，尽管它们有可能显着扩展从脑成像研究得出的结论的范围。鉴于在视觉及其障碍的研究中使用功能磁共振成像的急剧增加，开发，完善和验证技术，扩大可以使用功能磁共振成像解决的问题的范围是必要的。目前的建议具有这种潜力。