How does the central respiratory generator amplify sympathetic activity in hypertension?

中枢呼吸发生器如何增强高血压患者的交感神经活动？

• 批准号: nhmrc : 628838
• 负责人: Dr Anthony Pickering
• 金额: $ 19.34万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-central-respiratory-activity-hypertension/81419
• 关键词: How; does; central; respiratory; generator

High blood pressure causes many life-threatening cardiovascular diseases, including heart failure and stroke. The cause of most high blood pressure is not known. Using an animal model of high blood pressure we have shown that an interaction, in the brain, between the nerve pathways that generate respiratory activity and regulate blood pressure is altered. This occurs early in life and our evidence strongly suggests this may be a cause of high blood pressure.

高血压导致许多危及生命的心血管疾病，包括心力衰竭和中风。大多数高血压的原因尚不清楚。使用高血压的动物模型，我们已经表明，在大脑中，产生呼吸活动和调节血压的神经通路之间的相互作用被改变。这发生在生命的早期，我们的证据强烈表明这可能是高血压的原因。