Respiratory modulation of RVLM premotor neurons: role in the sympathetic over-activity of hypertension.

RVLM 前运动神经元的呼吸调节：在高血压交感神经过度活动中的作用。

• 批准号: nhmrc : 454432
• 负责人: Dr Anthony Pickering
• 金额: $ 22.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/respiratory-modulation-rvlm-activity-hypertension/82557
• 关键词: Respiratory; modulation; RVLM; premotor; neurons

Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular diseases, including heart failure and stroke. Whilst some effective therapies are available, many patients are not adequately treated or have reduced quality of life due to serious side effects. There is a great need for alternative therapies. The central nervous system is clearly involved in hypertension although the level of that involvement is not well understood- i.e. is it a causal factor or just a contributor to the maintenance of established hypertension? The experiments outlined in this application are based on the observation that modulation of nervous activity to blood vessels is more influenced by the respiratory system in people with high blood pressure, than in normotensive people. We aim to test whether this increased respiratory modulation might be involved in the generation of the high blood pressure.

高血压是所有社会中常见的健康障碍，并且是发展威胁生命的心血管疾病（包括心力衰竭和中风）的主要风险因素。虽然有一些有效的治疗方法，但许多患者没有得到充分的治疗或由于严重的副作用而降低了生活质量。替代疗法的需求很大。中枢神经系统显然与高血压有关，尽管其参与程度尚不清楚-即它是一个因果因素还是仅仅是维持已建立的高血压的一个因素？本申请中概述的实验是基于这样的观察，即神经活动对血管的调节在高血压患者中比在血压正常的人中更受呼吸系统的影响。我们的目的是测试这种增加的呼吸调节是否可能参与高血压的产生。