How does exercise ameliorate programming of metabolic dysfunction in offspring of obese mothers?

运动如何改善肥胖母亲后代的代谢功能障碍？

• 批准号: nhmrc : 1044295
• 负责人: Prof David Sinclair
• 金额: $ 34.95万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-exercise-ameliorate-obese-mothers/111647
• 关键词: How; does; exercise; ameliorate; programming

Obesity is a worldwide disease, reflecting an interaction between our environment (diet, physical activity) and genes. We know that a mother's unhealthy diet can predispose offspring to diabetes, and exercise can improve this, but the underlying mechanisms are poorly understood. Here we will examine how exercise can benefit offspring of obese mothers, and test a drug that mimics the effects of exercise. The proposed research will provide insight into ways of reducing the obesity epidemic.

肥胖是一种世界性疾病，反映了我们的环境(饮食、体力活动)和基因之间的相互作用。我们知道，母亲不健康的饮食会使孩子容易患上糖尿病，运动可以改善这一点，但其潜在的机制尚不清楚。在这里，我们将研究运动如何造福肥胖母亲的后代，并测试一种模拟运动效果的药物。这项拟议的研究将为减少肥胖症流行的方法提供洞察。