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HOW DOES RESERVE MODIFY LINKS BETWEEN COGNITION & IMAGING INDICES OF AD PATHOLOGY

储备如何改变认知之间的联系

基本信息

批准号：
8880085
负责人：
PRASHANTHI VEMURI
金额：
$ 24.15万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8880085
关键词：
Affect Aging Algorithms Alzheimer&apos s Disease Amyloid Area Attenuated Autopsy Brain Classification Clinical Cognition Cognitive Dementia Disease Education Elderly Evolution Exercise Financial compensation Functional Magnetic Resonance Imaging Goals Image Impaired cognition Individual Life Style Link Liquid substance Magnetic Resonance Imaging Measures Mentors Mentorship Methods Modality Modeling Molecular Nerve Degeneration Neuronal Dysfunction Neuronal Injury Occupations Pathologic Pathology Phase Physical activity Pittsburgh Compound-B Play Population Positron-Emission Tomography Prevention strategy Publishing Recovery Research Rest Role Scanning Senile Plaques Severities Source Time Training Vascular Diseases abstracting base cognitive ability cognitive function cognitive neuroscience cognitive performance cohort coping imaging biomarker imaging modality improved in vivo in vivo imaging indexing mild cognitive impairment neuropathology population based skills success

项目摘要

PROJECT SUMMARY/ABSTRACT Although pathology is the underlying cause of cognitive decline seen in Alzheimer's disease (AD), inter- subject variability in reserve mechanisms explains why some subjects have greater capacity to minimize the clinical expression of disease related neuropathological changes. The broad objective of this proposal is to investigate how measures of reserve modify the relationship between pathology and cognition. Pathology will be quantified using multi-modality PET and MRI imaging biomarkers. Mentored Phase: For Specific Aim 1 of the study, the candidate will extend her published results for automated quantification of neurodegeneration in AD from structural MRI (sMRI) to develop algorithms for quantifying in vivo imaging measures of pathology from other imaging modalities (PiB-PET: indicator of plaque burden; FDG-PET: indicator of neuronal dysfunction; FLAIR: indicator of cerebro-vascular disease along with sMRI: indicator of neurodegeneration). These algorithms will be applied to calculate modality-specific imaging measures of pathology in our non-demented population-based cohort consisting of cognitively normal and mild cognitive impairment subjects. During this time, she will receive direct mentorship from Dr. Clifford Jack in the area of multi-modality imaging methods in AD and Dr. David Knopman in clinical aspects of aging and dementia. As part of the proposed research, the candidate will take courses in cognitive neuroscience and clinical methods to strengthen the skill set necessary for the multi-disciplinary research outlined here. Independent Phase (R00): During this phase, measures of reserve will be identified from functional connectivity metrics derived from resting state fMRI and from other sources such as intellectual lifestyle (education, occupation, cognitive activities) and physical activity measure (physical activity and exercise). These will be applied (Aim 2) to establish the relationships between imaging measures of pathology and cognitive performance and how these relationships are modified by measures of reserve and by interactions with other imaging measures of pathology. And in Aim 3, establish the relationships between imaging measures of pathology and change in cognitive performance over time and how these relationships are modified by measures of reserve and by interactions with other imaging measures of pathology.

项目概要/摘要尽管病理学是阿尔茨海默病 (AD) 认知能力下降的根本原因，但储备机制的主体变异性解释了为什么某些主体有更大的能力将风险最小化疾病相关神经病理变化的临床表现。该提案的总体目标是研究储备措施如何改变病理学和认知之间的关系。将使用多模态 PET 和 MRI 成像生物标志物对病理学进行量化。指导阶段：对于该研究的具体目标 1，候选人将扩展其已发表的结果，以进行自动量化通过结构 MRI (sMRI) 研究 AD 中的神经退行性疾病，开发量化体内成像的算法其他成像方式的病理学测量（PiB-PET：斑块负荷指标；FDG-PET：神经元功能障碍的指标； FLAIR：脑血管疾病的指标以及 sMRI：脑血管疾病的指标神经退行性疾病）。这些算法将用于计算特定模态的成像测量我们的非痴呆人群队列中的病理学包括认知正常和轻度认知减值科目。在此期间，她将获得 Clifford Jack 博士在以下领域的直接指导： AD 的多模态成像方法以及 David Knopman 博士在衰老和痴呆症临床方面的研究。作为作为拟议研究的一部分，候选人将学习认知神经科学和临床方法课程加强此处概述的多学科研究所需的技能。独立相 (R00)：在此阶段，将从导出的功能连接指标中确定储备措施来自静息态功能磁共振成像和其他来源，例如智力生活方式（教育、职业、认知活动）和身体活动测量（身体活动和锻炼）。这些将应用于（目标 2）建立病理学成像测量与认知表现之间的关系以及这些测量如何关系通过储备措施和与其他成像措施的相互作用来改变病理。在目标 3 中，建立病理学成像测量与变化之间的关系随着时间的推移，认知表现以及这些关系如何通过储备措施和与其他病理学成像测量的相互作用。