Development Of A Vaccine For Leishmania Major Infection
开发利什曼原虫重大感染疫苗
基本信息
- 批准号:6987266
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:CpG islandsLeishmania majorPrimatesactive immunizationbiotechnologycellular immunitycytokinecytotoxic T lymphocytedosageenzyme linked immunosorbent assayhelper T lymphocytehistopathologyimmune responseinterleukin 12laboratory mouseleishmaniasisnonhuman therapy evaluationprotozoal antigenprotozoal vaccinerecombinant virusvaccine developmentvaccine evaluationvector vaccine
项目摘要
Infection with Leishmania causes significant morbidity and mortality worldwide. The type of Leishmania species infecting the host and the immune response generated by the host determines the spectrum of clinical disease that is seen. In particular, the pattern of cytokine production from T cells is critical for protection. At present there is no vaccine for Leishmania that is easy to administer, efficacious, and cost effective. These experiments will seek to establish a vaccine regimen that is sufficient to confer long-term protective immunity following infectious challenge in mice and primates. Experiments will specifically focus on DNA, protein and recombinant viral vaccines. In addition, these studies will evaluate the cellular and molecular mechanisms by which different vaccine formulations induce long-term protective cellular immunity.
利什曼原虫感染在世界范围内引起显著的发病率和死亡率。感染宿主的利什曼原虫种类和宿主产生的免疫应答决定了所观察到的临床疾病谱。特别是,T细胞产生细胞因子的模式对于保护至关重要。目前还没有一种易于管理、有效且具有成本效益的利什曼原虫疫苗。这些实验将寻求建立一种疫苗方案,该方案足以在小鼠和灵长类动物感染性攻击后赋予长期保护性免疫力。实验将特别侧重于DNA、蛋白质和重组病毒疫苗。此外,这些研究将评估不同疫苗制剂诱导长期保护性细胞免疫的细胞和分子机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ROBERT A SEDER其他文献
ROBERT A SEDER的其他文献
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{{ truncateString('ROBERT A SEDER', 18)}}的其他基金
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
用于预防病毒、寄生虫和分枝杆菌感染的 DNA 疫苗接种
- 批准号:
6288990 - 财政年份:
- 资助金额:
-- - 项目类别:
Factors Regulating T Helper Cell Memory Differentiation
调节 T 辅助细胞记忆分化的因素
- 批准号:
6822221 - 财政年份:
- 资助金额:
-- - 项目类别:
Optimization Of Hiv Specific Immune Responses In Vivo
体内 HIV 特异性免疫反应的优化
- 批准号:
6684235 - 财政年份:
- 资助金额:
-- - 项目类别:
Development of Pre-Erythrocytic Malaria Vaccines and antibodies
前红细胞疟疾疫苗和抗体的开发
- 批准号:
10683005 - 财政年份:
- 资助金额:
-- - 项目类别:
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