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Development of Pre-Erythrocytic Malaria Vaccines

Development of Pre-Erythrocytic Malaria Vaccines
前红细胞疟疾疫苗的开发
批准号：
8336405
负责人：
ROBERT A SEDER
金额：
$68.5万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8336405
关键词：
AdjuvantAntibodiesAreaAttenuatedBiological AssayBiteBloodCD4 Positive T LymphocytesCD8B1 geneClinical TrialsCulicidaeDevelopmentDrug FormulationsErythrocytesGoalsHumanHumoral ImmunitiesImmuneImmunityImmunizationImmunologic AdjuvantsInfectionLengthLiverMalariaMalaria VaccinesMeasuresModelingMusParasitesPhasePlasmodium falciparumPoly ICLCProteinsRadiationRouteSpleenSporozoite vaccineSporozoitesT cell responseT-LymphocyteVaccinesViral Vectorcircumsporozoite proteinimmunogenicityin vivonovelresponse

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英文摘要
The major discovery this year are as follows. 1. Performed a NHP vaccine and challenge study using Pk CSP Protein and Poly ICLC as an adjuvant with or without rAd5-CSP as a boost. Developed a mosquito challenge model for PK in NHP> 2. Showed that radiation attenuated sporozoites administered intravenously into NHP induced potent CD4 and CD8+ T cell responses in blood and liver. We also developed an assay to measure SPZ specific T cell responses. 3. Demonstrated that a novel full length P. falciparum CSP protein elicited potent CD4+ T cell and humoral immunity in mice sufficient to limit parasite replication in vivo following challenge.
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VACCINE DEVELOPMENT FOR TUBERCULOSIS
  • 批准号：
    7958684
  • 项目类别：
  • 资助金额：
    $5.57万
  • 财政年份：
    2009
  • 负责人：
    ROBERT A SEDER
  • 依托单位：
    TULANE UNIVERSITY OF LOUISIANA
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
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