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Development Of A Vaccine For Leishmania Major Infection

Development Of A Vaccine For Leishmania Major Infection
开发利什曼原虫重大感染疫苗
批准号：
9161749
负责人：
ROBERT A SEDER
金额：
$19.5万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9161749
关键词：
Activities of Daily LivingAdjuvantAntibodiesAntibody FormationAntigensCD4 Positive T LymphocytesCD8B1 geneCellular ImmunityCellular ImmunologyClinicalDevelopmentDiseaseDrug FormulationsEnhancing AntibodiesEquilibriumFlow CytometryGenerationsGoalsHIVImmuneImmune responseImmunityImmunizationInfectionInterferonsLeadLeishmaniaLeishmania majorLigandsMaintenanceMalariaMediatingModelingMorbidity - disease rateMusMycobacterium tuberculosisPatternPlayPolymersProductionProteinsRoleT cell responseT-LymphocyteTh1 CellsTh2 CellsToll-like receptorsToxic effectVaccinationVaccinesbasecost effectivecytokinekillingslymph nodesmortalitynonhuman primatenovelpathogenresponsevaccine development

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中文摘要
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英文摘要
Infection with Leishmania causes significant morbidity and mortality worldwide. The type of Leishmania species infecting the host and the immune response generated by the host determines the spectrum of clinical disease that is seen. In particular, the pattern of cytokine production from T cells is critical for protection. At present there is no vaccine for Leishmania that is easy to administer, efficacious, and cost effective. Over the past year we developed new way to deliver vaccines using polymers and immune enhances that together lead to more robust immune responses but limits any toxicity.
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VACCINE DEVELOPMENT FOR TUBERCULOSIS
  • 批准号：
    7958684
  • 项目类别：
  • 资助金额：
    $5.57万
  • 财政年份：
    2009
  • 负责人：
    ROBERT A SEDER
  • 依托单位：
    TULANE UNIVERSITY OF LOUISIANA
DNA VACCINATION FOR PREVENTION OF VIRAL, PARASITIC AND MYCOBACTERIAL INFECTION
Development Of A Vaccine For Leishmania Major Infection
Development Of A Vaccine For Leishmania Major Infection
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