A workplace multilevel intervention to reduce sugary beverage intake: Can the Compulsive Eating Phenotype guide better treatment matching, and does it work through predicted mechanisms of action?

减少含糖饮料摄入量的工作场所多层次干预：强迫性饮食表型能否指导更好的治疗匹配，是否通过预测的作用机制发挥作用？

• 批准号: 10666314
• 负责人: Elissa S. Epel
• 金额: $ 46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666314
• 关键词: Alcohols; Behavioral; Behavioral Mechanisms; Beverages; Binge Eating; Body Weight decreased; Clinical Trials; Consumption; Counseling; Data; Data Collection; Eating; Ecological momentary assessment; Effectiveness; Employee; Enrollment; Ethnic Origin; Excision; Exposure to; Feeling; Focus Groups; Food; Funding; Health; Healthcare Systems; Hospitals; Hyperphagia; Individual; Inflammation; Infrastructure; Insulin Resistance; Intake; Intervention; Investments; Link; Lipids; Maintenance; Measurement; Mediating; Mediation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic syndrome; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Occupational Groups; Occupational Status; Outcome; Parents; Patient Self-Report; Persons; Phenotype; Process Measure; Psychological Stress; Public Health; Race; Randomized; Randomized Controlled Trials; Reporting; Rewards; Risk Factors; Sales; Sampling; Satiation; Science; Self Efficacy; Stress; Subgroup; Testing; Text; Thinking; Time; Tobacco; Variant; Work; Workplace; arm; base; behavior change; behavior measurement; comparative efficacy; craving; dietary; drinking; effective intervention; efficacy outcomes; environmental intervention; experience; high risk; improved; intervention effect; intervention program; obesity treatment; post intervention; programs; racial and ethnic; recruit; standardize measure; sugar; sweetened beverage; treatment arm

A workplace multilevel intervention to reduce sugary beverage intake: Can the Compulsive Eating Phenotype guide better treatment matching, and does it work through predicted mechanisms of action? SUPPLEMENT ABSTRACT Sugar-sweetened beverages (SSBs) have emerged as a key dietary risk factor for obesity and type 2 diabetes. We have a new NIDDK-funded trial of the Metabolic Health Improvement Program (MHIP), a randomized controlled trial of a multilevel workplace intervention on a diverse sample, that combines an employer-sponsored sales ban on sugar sweetened beverages (SSBs) with brief counseling (recruitment beginning February 2023). This one-year supplement provides a time sensitive opportunity to build the scientific infrastructure to implement and conduct a thorough “science of behavior change” analysis of why an already successful multilevel intervention works, targeting three candidate mechanisms of change (cravings, stress, efficacy). We are focusing on the high-risk subgroup of those with compulsive eating, with implications for treatment matching, and exploring ethnic/racial and occupational group differences as well. We extend aims of the parent study to discover the MHIP multilevel intervention’s mechanisms of action. Based on our pilot data and focus groups, we propose that being high on the compulsive eating phenotype (CE) increases vulnerability to daily triggers of SSB intake – craving, psychological stress, low self-efficacy and that the brief counseling works in part through these mechanisms. This supplement will allow us to build the infrastructure to assess the CE phenotype, measure the process of change by adding frequent SMS text-based assessments of our proposed daily behavioral mediators (SSB craving, psychological stress, and self-efficacy) and outcome (SSB intake) at 6 timepoints (baseline, immediately post intervention, one month later after last booster session, and then during maintenance (3, 6, and 12 months later). We will characterize a high CE phenotype by assessing links with metabolic disease and high sugar intake (Aim 1), determine whether individuals with high CE synergistically benefit from a workplace multi-level intervention with sales ban and counseling (Aim 2), and ascertain whether any increased benefits are due to reduced daily behavioral mediators of SSB intake (craving, psychological stress, and self-efficacy) (Aim 3). Clarifying the mechanisms of action has importance for the broader science of behavior change and the creation of more effective interventions for obesity and metabolic disease.

减少含糖饮料摄入的工作场所多层次干预：强迫性饮食表型 指导更好的治疗匹配，它是否通过预测的作用机制发挥作用？ 资料摘要 含糖饮料（SSB）已成为肥胖和2型糖尿病的关键饮食风险因素。我们 有一个新的NIDDK资助的试验代谢健康改善计划（MHIP），随机对照试验， 对不同样本进行多层次的工作场所干预， 甜味饮料（SSB）与简短的咨询（招聘开始2023年2月）。 这一为期一年的补充提供了一个时间敏感的机会，以建立科学基础设施， 进行彻底的“行为改变科学”分析，为什么一个已经成功的多层次干预工作， 针对三个候选的改变机制（渴望，压力，效能）。我们关注的是 强迫性进食者，对治疗匹配的影响，以及探索种族/种族和职业 群体差异也是如此。 我们扩展了母研究的目的，以发现MHIP多级干预的作用机制。基于 我们的试点数据和焦点小组，我们提出，高的强迫性进食表型（CE）增加 易受SSB摄入的日常触发因素-渴望，心理压力，自我效能感低， 通过这些机制发挥作用。这份补充资料将使我们能够建立评估行政长官的基础设施 表型，通过增加频繁的短信文本为基础的评估，我们建议每天测量的变化过程 6个时间点的行为介质（SSB渴望、心理压力和自我效能）和结局（SSB摄入量） （基线，干预后立即，最后一次加强治疗后一个月，然后在维持期间（3，6， 12个月后）。 我们将通过评估与代谢疾病和高糖摄入的联系来表征高CE表型（目标1）， 确定具有高CE的个人是否协同受益于工作场所多层次的销售干预 禁令和咨询（目标2），并确定是否有任何增加的好处是由于减少日常行为介质 SSB摄入量（渴望，心理压力和自我效能）（目标3）。阐明作用机制， 对于更广泛的行为改变科学和创造更有效的肥胖干预措施的重要性， 代谢性疾病