A workplace multilevel intervention to reduce sugary beverage intake: Can the Compulsive Eating Phenotype guide better treatment matching, and does it work through predicted mechanisms of action?

减少含糖饮料摄入量的工作场所多层次干预：强迫性饮食表型能否指导更好的治疗匹配，是否通过预测的作用机制发挥作用？

• 批准号: 10666314
• 负责人: Elissa S. Epel
• 金额: $ 46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666314
• 关键词: Alcohols; Behavioral; Behavioral Mechanisms; Beverages; Binge Eating; Body Weight decreased; Clinical Trials; Consumption; Counseling; Data; Data Collection; Eating; Ecological momentary assessment; Effectiveness; Employee; Enrollment; Ethnic Origin; Excision; Exposure to; Feeling; Focus Groups; Food; Funding; Health; Healthcare Systems; Hospitals; Hyperphagia; Individual; Inflammation; Infrastructure; Insulin Resistance; Intake; Intervention; Investments; Link; Lipids; Maintenance; Measurement; Mediating; Mediation; Mediator of activation protein; Metabolic; Metabolic Diseases; Metabolic syndrome; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Occupational Groups; Occupational Status; Outcome; Parents; Patient Self-Report; Persons; Phenotype; Process Measure; Psychological Stress; Public Health; Race; Randomized; Randomized Controlled Trials; Reporting; Rewards; Risk Factors; Sales; Sampling; Satiation; Science; Self Efficacy; Stress; Subgroup; Testing; Text; Thinking; Time; Tobacco; Variant; Work; Workplace; arm; base; behavior change; behavior measurement; comparative efficacy; craving; dietary; drinking; effective intervention; efficacy outcomes; environmental intervention; experience; high risk; improved; intervention effect; intervention program; obesity treatment; post intervention; programs; racial and ethnic; recruit; standardize measure; sugar; sweetened beverage; treatment arm

A workplace multilevel intervention to reduce sugary beverage intake: Can the Compulsive Eating Phenotype guide better treatment matching, and does it work through predicted mechanisms of action? SUPPLEMENT ABSTRACT Sugar-sweetened beverages (SSBs) have emerged as a key dietary risk factor for obesity and type 2 diabetes. We have a new NIDDK-funded trial of the Metabolic Health Improvement Program (MHIP), a randomized controlled trial of a multilevel workplace intervention on a diverse sample, that combines an employer-sponsored sales ban on sugar sweetened beverages (SSBs) with brief counseling (recruitment beginning February 2023). This one-year supplement provides a time sensitive opportunity to build the scientific infrastructure to implement and conduct a thorough “science of behavior change” analysis of why an already successful multilevel intervention works, targeting three candidate mechanisms of change (cravings, stress, efficacy). We are focusing on the high-risk subgroup of those with compulsive eating, with implications for treatment matching, and exploring ethnic/racial and occupational group differences as well. We extend aims of the parent study to discover the MHIP multilevel intervention’s mechanisms of action. Based on our pilot data and focus groups, we propose that being high on the compulsive eating phenotype (CE) increases vulnerability to daily triggers of SSB intake – craving, psychological stress, low self-efficacy and that the brief counseling works in part through these mechanisms. This supplement will allow us to build the infrastructure to assess the CE phenotype, measure the process of change by adding frequent SMS text-based assessments of our proposed daily behavioral mediators (SSB craving, psychological stress, and self-efficacy) and outcome (SSB intake) at 6 timepoints (baseline, immediately post intervention, one month later after last booster session, and then during maintenance (3, 6, and 12 months later). We will characterize a high CE phenotype by assessing links with metabolic disease and high sugar intake (Aim 1), determine whether individuals with high CE synergistically benefit from a workplace multi-level intervention with sales ban and counseling (Aim 2), and ascertain whether any increased benefits are due to reduced daily behavioral mediators of SSB intake (craving, psychological stress, and self-efficacy) (Aim 3). Clarifying the mechanisms of action has importance for the broader science of behavior change and the creation of more effective interventions for obesity and metabolic disease.

减少含糖饮料摄入量的工作场所多层次干预：强迫性进食表型能否 指导更好的治疗匹配，它是否通过预测的作用机制起作用？ 增刊摘要 含糖饮料(SSB)已成为肥胖和2型糖尿病的关键饮食风险因素。我们 有一项由NIDDK资助的新陈代谢健康改善计划(MHIP)的新试验，这是一项关于 对不同样本的多层次工作场所干预，结合了雇主赞助的糖销售禁令 加糖饮料(SSB)，提供短暂咨询(从2023年2月开始招募)。 这一为期一年的补充资料提供了一个时间敏感的机会，以建立科学基础设施，以实施和 对已经成功的多层次干预为什么有效进行彻底的“行为改变科学”分析， 针对三种候选的改变机制(渴望、压力、有效性)。我们把重点放在高危人群上 那些有强迫性饮食的人，对治疗匹配和探索民族/种族和职业的影响 群体差异也是如此。 我们扩展了母体研究的目标，以发现MHIP多水平干预的作用机制。基于 我们的试点数据和焦点小组，我们认为强迫性进食表型(CE)增加 易受SSB摄入的日常触发因素--渴望、心理压力、低自我效能感和短暂的咨询 在一定程度上是通过这些机制发挥作用。这份补充资料将使我们能够建立评估行政长官的基础设施 表型，通过添加对我们建议的日常生活的频繁短信文本评估来衡量变化的过程 6个时间点的行为中介(SSB渴望、心理压力和自我效能)和结果(SSB摄入量) (基线、干预后立即、最后一次助推器会议后一个月，然后在维护期间(3、6和 12个月后)。 我们将通过评估与代谢性疾病和高糖摄入的联系来表征高CE表型(目标1)。 确定CE高的个人是否从工作场所对销售的多层次干预中协同受益 禁食和咨询(目标2)，并确定任何增加的好处是否源于日常行为调解人的减少 SSB摄入量(渴望、心理压力和自我效能感)(目标3)。澄清其作用机制 对更广泛的行为改变科学和创造更有效的肥胖干预措施的重要性 代谢性疾病。