Laser Spectroscopy of the Cornea
角膜激光光谱检查
基本信息
- 批准号:6951137
- 负责人:
- 金额:$ 19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-05-01 至 2007-04-30
- 项目状态:已结题
- 来源:
- 关键词:biomarkerbiomedical equipment developmentbiotechnologyburnscomputer assisted diagnosiscorneadiagnosis quality /standardfluorescencefluorescence spectrometryhistopathologyhuman tissuelaboratory rabbitlaser spectrometryorgan culturerefractive keratoplastytechnology /technique developmenttime resolved datatissue engineering
项目摘要
DESCRIPTION: (Applicant's Abstract) Dr. Roy Chuck is an M.D., Ph.D. who
obtained his degrees from Columbia University under auspices of the National
Institutes of Health's prestigious Medical Scientist Training Program Prior to
that he obtained an Engineering Science degree from the University of
California al Berkeley. He possesses a unique background that encompasses the
fields of laser spectroscopy, biochemistry and ophthalmology.
The long term objective of this application is to characterize the
spectroscopic properties of the cornea during ultraviolet laser ablation to
allow identification of spectral features that ma3 differentiate normal from
diseased tissue. Specifically, this will be accomplished by the measurement of
laser-induced fluorescence in real-time during 193-nm excimer laser corneal
surger3 in various normal and disease states including chemical burns and
diabetes.
All of the data taken together, besides enhancing our knowledge of the spectral
features of the cornea in various disease states of ocular health, may also
result in the bioengineering development of an instrument to guide the
alteration of excimer laser ablative patterns to achieve more predictable
surgical results by using real-time spectroscopic feedback information.
Much of the work will be accomplished at the Beckman Laser Institute at the
University of California, Irvine which is well equipped to support the in vivo
and clinical studies of excimer laser corneal surgery and vision within this
research program. The Beckman Laser Institute which is located quite close to
the department offices is closely affiliated with the Department of
Ophthalmology. Housed within the Beckman Laser Institute is a clinical excimer
laser that will be used for this study (VISX Star2). In addition, the Beckman
Laser Institute contains a fully equipped vivarium for housing of rabbits, the
experimental animal that will be used in these investigations Core histology
and ultrastructure facilities are also available within the institute.
The UCI Department of Ophthalmology has an active cornea and external disease
service. This clinical practice will provide the patients for the clinical
studies in the final phase of this research.
描述:(申请人的摘要)Roy Chuck博士是医学博士,博士谁
在国家科学院的赞助下,他获得了哥伦比亚大学的学位。
卫生研究院著名的医学科学家培训计划之前,
他在纽约大学获得了工程科学学位,
加州伯克利。他拥有独特的背景,
激光光谱学、生物化学和眼科学领域。
本申请的长期目标是表征
在紫外激光消融过程中角膜的光谱特性,
允许识别区分正常和异常的光谱特征
病变组织具体而言,这将通过测量
193nm准分子激光角膜术中实时激光诱导荧光
外科医生3处于各种正常和疾病状态,包括化学烧伤,
糖尿病
所有的数据加在一起,除了增强我们对光谱的了解外,
在眼睛健康的各种疾病状态下的角膜特征也可以
导致生物工程开发的仪器,以指导
改变准分子激光烧蚀图案以实现更可预测的
通过使用实时光谱反馈信息来评估手术结果。
大部分工作将在贝克曼激光研究所完成。
加州尔湾大学,设备齐全,支持体内
准分子激光角膜手术和视力的临床研究
研究计划。贝克曼激光研究所位于相当接近
该部门的办公室是密切隶属于该部的
眼科贝克曼激光研究所内有一台临床准分子激光器,
本研究将使用的激光(VISX Star 2)。此外,贝克曼
激光研究所包含一个设备齐全的饲养兔子的动物园,
将用于这些研究的实验动物
和超微结构设备也可在研究所内使用。
UCI眼科有活动性角膜和外部疾病
的服务.该临床实践将为患者提供临床
在这项研究的最后阶段。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A technique to harvest Descemet's membrane with viable endothelial cells for selective transplantation.
- DOI:10.1016/j.ajo.2004.09.068
- 发表时间:2005-02
- 期刊:
- 影响因子:4.2
- 作者:Teresa S. Ignacio;Thao T B Nguyen;M. Sarayba;P. Sweet;O. Piovanetti;R. Chuck;A. Behrens
- 通讯作者:Teresa S. Ignacio;Thao T B Nguyen;M. Sarayba;P. Sweet;O. Piovanetti;R. Chuck;A. Behrens
High expression of macrophage migration inhibitory factor in the murine lacrimal gland.
小鼠泪腺中巨噬细胞迁移抑制因子的高表达。
- DOI:10.1097/ico.0b013e3181c06466
- 发表时间:2010
- 期刊:
- 影响因子:2.8
- 作者:Park,ChoulYong;Shin,YoungJoo;Lekhanont,Kaevalin;Zhang,Cheng;Lee,Woo-Seok;Cano,Marisol;Bucala,Richard;Chuck,RoyS
- 通讯作者:Chuck,RoyS
Endothelial lamellar keratoplasty using an artificial anterior chamber and a microkeratome.
使用人工前房和微型角膜刀进行内皮板层角膜移植术。
- DOI:10.1001/archopht.121.4.503
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Behrens,Ashley;Ellis,Kenneth;Li,Li;Sweet,PaulaM;Chuck,RoyS
- 通讯作者:Chuck,RoyS
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Roy S Chuck其他文献
Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligand.
过氧化物酶体增殖物激活受体-γ配体抑制角膜新生血管。
- DOI:
- 发表时间:
2005 - 期刊:
- 影响因子:3.4
- 作者:
M. Sarayba;Li Li;Tulaya Tungsiripat;Norman H Liu;P. Sweet;Anup J. Patel;Kathryn E Osann;Amar Chittiboyina;S. Benson;H. Pershadsingh;Roy S Chuck - 通讯作者:
Roy S Chuck
Roy S Chuck的其他文献
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{{ truncateString('Roy S Chuck', 18)}}的其他基金
A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn
一种利用微管促进碱性烧伤后角膜伤口愈合的新型疗法
- 批准号:
9894005 - 财政年份:2019
- 资助金额:
$ 19万 - 项目类别: