UKY DENTAL COBRE: DENTAL CLINICAL RESEARCH CENTER

英国 DENTAL COBRE：牙科临床研究中心

• 批准号: 6972169
• 负责人: Michael John Novak
• 金额: $ 34.64万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-23 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6972169
• 关键词: chronic disease /disorder; clinical research; infection; inflammation; oral bacteria

The clinical research environment at the University of Kentucky is excellent. UK currently supports training through an institutional K30 award, "Career Training in Therapeutics & Translational Research", from NIH that provides career development and mentoring opportunities for clinician-scientists interested in pursuing careers in clinical research. There are currently two full time faculty of the college of dentistry pursuing clinical research training through the K30 award. However, the K30 award does not lead to a degree but provides certification of participation in a clinical research training program. Dr. Dawson (Project 5) and Dr. Cunningham (Pilot Project 1) are integrating with this program for clinical research training. The University of Kentucky Clinical Research Organization (UKCRO) is an institutionally funded center that provides regular seminars and training opportunities for clinicians and study coordinators. In addition, the UKCRO offers regulatory assistance with grants and clinical trials, assists in subject recruitment, as well as in the training and certification of research coordinators and staff. Working closely with the UKCRO, the NIH funded General Clinical Research Center (GCRC) provides seed funding for clinical projects, as well as nursing, laboratory and statistical support. The COHR has provided the focus for developing a new research culture at the College and has been the organizational structure for acquiring new laboratory and clinical research space. These activities have enabled the College to increase its research portfolio to include NIH, HRSA, Kentucky Science and Technology Center, foundation, and private company research and education funding over the last 2 1/2 years. A major University goal is to become one of the top 20 public research institutions by 2020 and a key COHR strategy is to build a responsive, rigorous, productive clinical research unit. As a result of a donation of $750,000 from the Delta Dental Plan of Kentucky and a matching donation of $750,000 from The Commonwealth of Kentucky Research Challenge Trust Fund, an endowment has been established to support the Delta Dental Plan of Kentucky Clinical Research Center (DDKCRC). The DDKCRC occupies 2,000 sq. ft. of newly renovated space in the UKCD. Renovations were funded by the Associate Vice President for Research. The clinical research initiatives of the COHR are coordinated in the DDKCRC, by Dr. M. John Novak, B.D.S., L.D.S., M.S., Ph.D., the Associate Director of the COHR overseeing 4 hygienists/study coordinators, and a research associate clinician who manages the operations of the clinic. A primary focus of the DDKCRC is to create a research infrastructure to: 1) develop and train clinical research professionals, research coordinators, and research staff and 2) define and impact oral health disparities in rural communities of Kentucky. An initial emphasis will be on investigations to determine oral-systemic disease linkages in these rural populations, and to define biological, genetic, and socio-behavioral factors contributing to these disparities.

肯塔基大学的临床研究环境非常优越。英国目前通过 NIH 颁发的机构 K30 奖项“治疗学和转化研究职业培训”来支持培训，该奖项为有兴趣从事临床研究职业的临床医生科学家提供职业发展和指导机会。目前，牙科学院有两名全职教师通过 K30 奖项进行临床研究培训。然而，K30 奖项并不授予学位，而是提供参与临床研究培训计划的认证。 Dawson 博士（项目 5）和 Cunningham 博士（试点项目 1）正在与该项目整合以进行临床研究培训。肯塔基大学临床研究组织 (UKCRO) 是一个机构资助的中心 为临床医生和研究协调员提供定期研讨会和培训机会。此外，UKCRO 还提供拨款和临床试验方面的监管援助，协助受试者招募以及研究协调员和工作人员的培训和认证。 NIH 资助的普通临床研究中心 (GCRC) 与 UKCRO 密切合作，为临床项目以及护理、实验室和统计支持提供种子资金。 COHR 为学院发展新的研究文化提供了重点，并成为获得新实验室和临床研究空间的组织结构。这些活动使学院在过去 2.5 年里增加了其研究组合，包括 NIH、HRSA、肯塔基科学技术中心、基金会和私营公司的研究和教育资助。大学的主要目标是到 2020 年成为排名前 20 的公共研究机构之一，COHR 的一项关键战略是建立一个反应灵敏、严谨、富有成效的临床研究单位。由于肯塔基州三角洲牙科计划捐赠了 75 万美元，肯塔基州研究挑战信托基金也捐赠了 75 万美元，因此设立了一项捐赠基金来支持 肯塔基州临床研究中心 (DDKCRC) 的 Delta 牙科计划。 DDKCRC 占地 2,000 平方英尺，位于 UKCD 新装修的空间中。翻修工程由负责研究的副总裁资助。 COHR 的临床研究计划由 DDKCRC 协调，由 M. John Novak 博士（B.D.S.、L.D.S.、M.S.、Ph.D.）负责协调，他是 COHR 的副主任，负责监督 4 名卫生员/研究协调员，以及一名管理诊所运营的副临床医生。 DDKCRC 的主要重点是创建研究基础设施，以：1) 培养和培训临床研究专业人员、研究协调员和研究人员，2) 确定和影响肯塔基州农村社区的口腔健康差异。最初的重点将放在调查上，以确定这些农村人口中口腔系统疾病的联系，并确定造成这些差异的生物、遗传和社会行为因素。