UKY DENTAL COBRE: DENTAL CLINICAL RESEARCH CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 DDKCRC的一个主要重点是创建一个研究基础设施，以：1)培养和培训临床研究专业人员、研究协调员和研究人员，以及2)确定和影响肯塔基州农村社区的口腔健康差距。最初的重点将是调查，以确定这些农村人口中口腔-全身疾病的联系，并确定导致这些差异的生物、遗传和社会行为因素。该中心的人员主要负责为中心的项目4、5和6准备和提交内部审查委员会批准的表格。所有这些都已获得并启动了项目。这些人员为这些项目招募病人以及为这些项目收集生物标本作出了贡献。此外，DDKCRC还将支持阿尔茨海默病-S病试点项目(斯坦博士)和新的吸烟基因完整项目(Al-Sabbagh博士)的临床研究需求。最后，DDKCRC的实验室人员为项目2、4、5和6的宿主分析物的评估提供了支持。此外，实验室还开发了一种实时定量聚合酶链式反应方法来评估龈下菌斑中的目标微生物，从而改进了对项目4、5和6中微生物变化的评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A primary focus of the DDKCRC is to create a research infrastructure to: 1) develop and train clinical research professionals, research coordinators, and research staff and 2) define and impact oral health disparities in rural communities of Kentucky. An initial emphasis will be on investigations to determine oral-systemic disease linkages in these rural populations, and to define biological, genetic, and socio-behavioral factors contributing to these disparities. The DDKCRC personnel have focused on the preparation and submission of forms for IRB approval for Projects 4, 5 and 6 for the center. These have all been obtained and the projects initiated. The personnel have contributed to the recruitment of patients for these same projects, as well as collecting biological specimens for the projects. In addition, the DDKCRC will be supporting the clinical research needs of the Pilot Project on Alzheimer?s Disease (Dr. Stein) and the new full project on Smoking Genotypes (Dr. Al-Sabbagh). Finally, the laboratory personnel in the DDKCRC, have provided support for evaluation of host analytes for Projects 2, 4, 5, and 6. In addition, the laboratory has developed a real-time quantitative PCR methodology for assessment of target microorganisms in the subgingival plaque allowing improved evaluation of microbial changes in Projects 4, 5 and 6.