UKY DENTAL COBRE: DENTAL CLINICAL RESEARCH CENTER

英国 DENTAL COBRE：牙科临床研究中心

• 批准号: 7610650
• 负责人: Michael John Novak
• 金额: $ 22.8万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610650
• 关键词: Alzheimer' s Disease; Behavioral; Biological; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dental; Evaluation; Funding; Genetic; Genotype; Grant; Human Resources; Institution; Investigation; Kentucky; Laboratories; Laboratory Personnel; Methodology; Oral; Oral health; Patient Recruitments; Pilot Projects; Polymerase Chain Reaction; Preparation; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Rural Community; Rural Population; Smoking; Source; Specimen; Systemic disease; Time; Training; United States National Institutes of Health; health disparity; improved; microbial; microorganism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A primary focus of the DDKCRC is to create a research infrastructure to: 1) develop and train clinical research professionals, research coordinators, and research staff and 2) define and impact oral health disparities in rural communities of Kentucky. An initial emphasis will be on investigations to determine oral-systemic disease linkages in these rural populations, and to define biological, genetic, and socio-behavioral factors contributing to these disparities. The DDKCRC personnel have focused on the preparation and submission of forms for IRB approval for Projects 4, 5 and 6 for the center. These have all been obtained and the projects initiated. The personnel have contributed to the recruitment of patients for these same projects, as well as collecting biological specimens for the projects. In addition, the DDKCRC will be supporting the clinical research needs of the Pilot Project on Alzheimer?s Disease (Dr. Stein) and the new full project on Smoking Genotypes (Dr. Al-Sabbagh). Finally, the laboratory personnel in the DDKCRC, have provided support for evaluation of host analytes for Projects 2, 4, 5, and 6. In addition, the laboratory has developed a real-time quantitative PCR methodology for assessment of target microorganisms in the subgingival plaque allowing improved evaluation of microbial changes in Projects 4, 5 and 6.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 DDKCRC的主要重点是创建研究基础设施：1）开发和培训临床研究专业人员，研究协调员和研究人员以及2）在肯塔基州农村社区中定义和影响口腔健康差异。 最初的重点将放在调查上，以确定这些农村人群中的口腔系统疾病联系，并定义导致这些差异的生物学，遗传和社会行为因素。 DDKCRC人员专注于为该中心的项目4、5和6提出IRB批准的表格。 这些都已获得并启动了项目。 人员为这些相同项目的患者招募以及为项目收集生物标本做出了贡献。 此外，DDKCRC将支持阿尔茨海默氏病（Stein博士）试点项目的临床研究需求和新的吸烟基因型完整项目（Al-Sabbagh博士）。 最后，DDKCRC中的实验室人员为评估项目2、4、5和6的宿主分析物提供了支持。此外，实验室已经开发了一种实时定量PCR方法，用于评估副本斑块中目标微生物的实时定量方法，从而可以改善项目4、5和6的微生物变化。