UKY DENTAL COBRE: DENTAL CLINICAL RESEARCH CENTER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 DDKCRC的主要重点是创建一个研究基础设施：1）开发和培训临床研究专业人员，研究协调员和研究人员，2）定义和影响肯塔基州农村社区的口腔健康差异。 最初的重点将是调查，以确定这些农村人口的口腔系统疾病的联系，并确定生物，遗传和社会行为因素，这些差异。 DDKCRC工作人员专注于为所有项目编制和提交IRB批准表格。 这些都已获得，项目也已启动。 这些人员为这些项目招募病人，并为项目收集生物标本。 最后，DDKCRC的实验室人员为所有项目的各种生物液体中的宿主分析物的评价提供支持。 此外，该实验室还开发了一种实时定量PCR方法，用于评估龈下菌斑中的目标微生物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A primary focus of the DDKCRC is to create a research infrastructure to: 1) develop and train clinical research professionals, research coordinators, and research staff and 2) define and impact oral health disparities in rural communities of Kentucky. An initial emphasis will be on investigations to determine oral-systemic disease linkages in these rural populations, and to define biological, genetic, and socio-behavioral factors contributing to these disparities. The DDKCRC personnel have focused on the preparation and submission of forms for IRB approval for all projects. These have all been obtained and the projects initiated. The personnel contribute to the recruitment of patients for these same projects, as well as collecting biological specimens for the projects. Finally, the laboratory personnel in the DDKCRC, provide support for evaluation of host analytes in various biological fluids for all projects. In addition, the laboratory has developed a real-time quantitative PCR methodology for assessment of target microorganisms in the subgingival plaque.