How does NF-kB2 regulate thymic selection to prevent organ-specific autoimmune disease?

NF-kB2 如何调节胸腺选择以预防器官特异性自身免疫性疾病？

• 批准号: nhmrc : 1107464
• 负责人: Dr Stephen Daley
• 金额: $ 54.21万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-nf-kb2-autoimmune-disease/662982
• 关键词: How; does; NF; kB2; regulate

Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.

自身免疫性疾病，如1型糖尿病和甲状腺炎，是由免疫系统的缺陷引起的，这些缺陷导致免疫系统混淆了自我和非自我。正常情况下，这种区别是在胸腺中编程的。我们最近发现了导致一种自身免疫性疾病的基因。我们还发现了一个重要的发现，即胸腺是如何调节自我和非自我的辨别力的。我们将在这两个发现的基础上，精确了解免疫系统通常如何避免自身免疫性疾病。