How does NF-kB2 regulate thymic selection to prevent organ-specific autoimmune disease?

自身免疫性疾病，如1型糖尿病和甲状腺炎，是由免疫系统的缺陷引起的，这些缺陷导致免疫系统混淆了自我和非自我。正常情况下，这种区别是在胸腺中编程的。我们最近发现了导致一种自身免疫性疾病的基因。我们还发现了一个重要的发现，即胸腺是如何调节自我和非自我的辨别力的。我们将在这两个发现的基础上，精确了解免疫系统通常如何避免自身免疫性疾病。

Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.