High Field MRI/MRS System for Non-human Primates

非人类灵长类动物高场 MRI/MRS 系统

• 批准号: 6815791
• 负责人: MALCOLM J AVISON
• 金额: $ 200万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6815791
• 关键词: Anthropoidea; bioimaging /biomedical imaging; biomedical equipment purchase; brain mapping; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant):This application from Vanderbilt University seeks partial funding for the acquisition of a state-of-the-art high field (4.7T) wide bore (60cm) vertical Magnetic Resonance Imaging/Spectroscopy system optimized for studies of the CNS in non-human primates (NHP). This system is essential for several current NIH-funded projects of the structural and functional neuroanatomy of the NHP brain. It is also essential for several projects addressing the fundamental biophysical origins of the fMRI BOLD response. The proposed facility will provide a major new capability for in vivo imaging and spectroscopy in NHPs, thereby permitting current NIH-funded investigators to undertake studies, which are beyond the scope and/or capabilities of existing equipment. MR studies in NHPs at Vanderbilt are currently restricted to a clinical 3T system, and are limited in scope to brief pre-operative stereotaxic studies to guide electrode placement. The new instrument will acquire structural and functional images and spectra that have inherently higher signal to noise ratios, greater spatial and spectral resolution, and images that are more sensitive to some contrast mechanisms. The proposed system will have shim, gradient, and r.f. coils and other associated hardware that are optimized for NHP studies, and will be based upon a modem console and spectrometer capable of a wide array of modem experiments. These new capabilities will include fast and 3D imaging at very high resolution, improved diffusion weighting and diffusion tensor imaging for white matter tractography, and broad-band multi-nuclear (1H, 31P, 13C etc.) in vivo MR spectroscopy for studies of regional metabolism. The system will be an integral part of the newly created Vanderbilt University Institute of Imaging Science (VUIIS), and will be housed in a newly constructed building with a bay already dedicated to and designed for a high field NHP scanner. It will be supported by a large and experienced group of physicists, engineers and computer scientists, and a well trained and qualified support staff, including electronic engineers and animal technologists. These technical experts will assist users in experimental design, data acquisition and data analysis. The proposed instrument will be a multi-user facility, supervised by a director and a core staff, developed and managed via an operating committee, and with oversight by an advisory committee charged with the responsibility of assuring appropriate access to NIH funded investigators. The proposed instrument will significantly increase the number and quality of investigations using NHPs, and will help Vanderbilt University meet its commitment to enhancing basic and clinical neuroscience research.

描述(由申请人提供)：这份来自范德比尔特大学的申请寻求部分资金，用于购买最先进的高场(4.7T)宽口径(60厘米)垂直磁共振成像/光谱系统，该系统最适合研究非人类灵长类动物(NHP)的中枢神经系统(CNS)。该系统对目前由美国国立卫生研究院资助的几个NHP脑结构和功能神经解剖学项目至关重要。这对于解决fMRI大胆反应的基本生物物理来源的几个项目也是至关重要的。拟议中的设施将为NHP的活体成像和光谱分析提供重大的新能力，从而允许目前由NIH资助的研究人员进行超出现有设备范围和/或能力的研究。范德比尔特NHP的MR研究目前仅限于临床3T系统，范围仅限于简单的术前立体定位研究，以指导电极放置。新仪器将获得结构和功能图像和光谱，这些图像和光谱具有固有的更高的信噪比、更高的空间和光谱分辨率，以及对某些对比机制更敏感的图像。建议的系统将具有垫片、渐变和R.F.线圈和其他相关硬件，为NHP研究进行了优化，并将基于能够进行各种现代实验的调制解调器控制台和光谱仪。这些新功能将包括非常高分辨率的快速和3D成像，用于白质束成像的改进的扩散加权和扩散张量成像，以及宽带多核(1H、31P、13C等)。活体核磁共振波谱用于区域代谢研究。该系统将是新成立的范德比尔特大学成像科学研究所(VUIIS)的组成部分，并将安装在一座新建的建筑中，该建筑的一个隔间已经专门用于高场NHP扫描仪，并为其设计。它将得到一大批经验丰富的物理学家、工程师和计算机科学家以及训练有素、合格的支持人员的支持，其中包括电子工程师和动物技术专家。这些技术专家将协助用户进行实验设计、数据采集和数据分析。拟议的工具将是一个多用户设施，由一名主任和一名核心工作人员监督，通过一个运营委员会开发和管理，并由一个咨询委员会监督，该咨询委员会负责确保适当接触NIH资助的调查人员。拟议的工具将显著增加使用NHP进行研究的数量和质量，并将帮助范德比尔特大学履行其加强基础和临床神经科学研究的承诺。