课题基金 / 基金详情

项目摘要

项目成果

MALCOLM J AVISON的其他基金

相似基金

相关文献

中文摘要
翻译
所建议的研究的长期目标是发展、验证和传播一套可推广的
英文摘要
The long term goal of the proposed research is to develop, validate and disseminate a set of generalizable methods for non-invasive mapping of the spatio-temporal dynamics of functional and structural plastic changes in the primate CNS using MRI. It outlines a strategy for improving MRI methods for measuring CNS plasticity, together with tools that allow the high resolution MRI observations to link changes in local and cellular electrophysiological properties on the one hand, to plastic changes in distributed brain circuits on the other, providing a methodological bridge across scales. The specific tools include optimized, translational, MR approaches for multiscale structural and functional brain imaging and high precision (sub-millimeter) methods for MRI and multi-modality intra- and inter-subject co-registration. The methods will be developed and tested using a well-characterized non-human primate model, and will be validated using “gold standard” highresolution mapping tools including functional optical imaging of intrinsic signal (OIS), dense array electrode mapping, and tissue histology. With these goals in mind, the proposal’s Specific Aims are: Aim 1) To refine and test the limits of MRI for mapping and characterizing functional and structural plasticity with sub-millimeter resolution in intact animals. Aim 2) To develop integrated imaging and post-processing tools that allow high precision coregistration of MR images in the same animal longitudinally and across multiple modalities.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1371/journal.pone.0094943
发表时间: 2014
期刊: PloS one
影响因子: 3.7
作者: [Majeed W, Avison MJ]
通讯作者: Avison MJ
Co-registration of high resolution MRI scans with partial brain coverage in non-human primates.
非人类灵长类动物的高分辨率 MRI 扫描与部分大脑覆盖的共同配准。
DOI: 10.1117/12.877024
发表时间: 2011
期刊: Proceedings of SPIE--the International Society for Optical Engineering
影响因子: --
作者: [Lecoeur,Jérémy, Wang,Feng, Chen,LiMin, Li,Rui, Avison,MalcomJ, Dawant,BenoitM]
通讯作者: Dawant,BenoitM
DOI: 10.1016/j.neuroimage.2016.08.015
发表时间: 2016-11-15
期刊: NeuroImage
影响因子: 5.7
作者: [Qi HX, Wang F, Liao CC, Friedman RM, Tang C, Kaas JH, Avison MJ]
通讯作者: Avison MJ
High Resolution MRI Mapping of CNS Plasticity
  • 批准号:
    7690629
  • 项目类别:
  • 资助金额:
    $66.78万
  • 财政年份:
    2009
  • 负责人:
    MALCOLM J AVISON
  • 依托单位:
ADHD IN FETAL DRUG AND ALCOHOL EXPOSURE
  • 批准号:
    7731470
  • 项目类别:
  • 资助金额:
    $0.04万
  • 财政年份:
    2006
  • 负责人:
    MALCOLM J AVISON
  • 依托单位:
ADHD IN FETAL DRUG AND ALCOHOL EXPOSURE
  • 批准号:
    7605646
  • 项目类别:
  • 资助金额:
    $0.9万
  • 财政年份:
    2006
  • 负责人:
    MALCOLM J AVISON
  • 依托单位:
Neural Bases of ADHD in Fetal Drug or Alcohol Exposure
  • 批准号:
    7058926
  • 项目类别:
  • 资助金额:
    $40.1万
  • 财政年份:
    2005
  • 负责人:
    MALCOLM J AVISON
  • 依托单位:
海外基金