Shared Computational Resource for Functional Genomics

描述(由申请人提供)： 华盛顿大学(UW)功能基因组学计算中心目前支持来自4个机构和26个系的53名PI和152名研究人员组成的不同小组的各种研究项目。这种支持主要包括：高端分析引擎(Rosetta Resolver)、定制数据库(Expression数组管理器或EAM)、数据存储和日常备份(目前超过2TB的数据)和各种辅助软件包和数据库，包括：Affymetrix MAS 5.0、Spot-on Tools-本地编写的基因表达软件包、与EAM集成的SpotFire Decision Site服务器、公共基因表达数据服务器-www.expsion.washington.edu和GCG序列分析软件。数据存储、数据库和高端分析工具(解析器、GCG和基因组数据库)目前通过一个已有四年历史的计算机系统提供，该计算机系统由2个Sun 6500‘S、3个Sun E4500’S和一个Clarion RAID阵列和ATL P3000磁带备份系统组成。该系统正在迅速接近其使用寿命，在该系统上增加一年的维护和支持费用将花费大约260,000美元。此外，由于华盛顿大学社区和我们的合作者越来越多地使用微阵列技术，用户群体的规模大约每1.5年翻一番。 我们建议购买一个完全配置的Sun计算机系统来取代目前老化的计算环境，该系统包括一台V880服务器、1TB磁盘阵列和磁带备份系统。这台服务器将使我们的维护和支持成本减少约四分之一，使我们能够继续为我们目前庞大的用户群提供可靠的服务，并将提供足够的计算能力来支持未来的扩张。

DESCRIPTION (provided by applicant): The University of Washington (UW), functional genomics computing center currently supports a wide variety of research projects from a diverse group of more than 53 PI's and 152 researchers spanning 4 institutions and 26 departments. This support consists primarily of: a high-end analysis engine (Rosetta Resolver), a custom database (Expression Array Manager or EAM), data storage and daily backup (currently more than 2 terabytes of data) and a variety of ancillary software packages and databases including: Affymetrix MAS 5.0, Spot-On tools -a gene expression software package written locally, SpotFire Decision Site server- integrated with EAM, a public gene expression data server - www.expression.washington.edu and GCG sequence analysis software. The data storage, databases and high-end analysis tools (Resolver, GCG and the genome databases) are currently provided via a four year old computer system consisting of 2 Sun 6500's, 3 Sun E4500's a Clarion RAID array and ATL P3000 tape backup system. This system is rapidly approaching its useful lifespan and to add a year of maintenance and support costs on this system would cost approximately $260,000. In addition, the size of the user group is roughly doubling every 1.5 years due to increased use of microarray technology by the UW community and our collaborators. We propose to replace the current aging computing environment with the purchase of a fully configured Sun computer system consisting of a V880 server, 1Terabyte disk array and tape backup system. This server will reduce our maintenance and support costs by approximately 1/4, will allow us to continue to provide reliable service to our current large user base and will provide sufficient computing power to permit future expansion.