Export of PfEMP1, the major virulence protein of P. falciparum, to the parasite-infected erythrocyte surface

将恶性疟原虫的主要毒力蛋白 PfEMP1 输出到寄生虫感染的红细胞表面

• 批准号: nhmrc : 1011453
• 负责人: Dr Melanie Rug
• 金额: $ 39.24万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/export-pfemp1-major-erythrocyte-surface/109585
• 关键词: Export; PfEMP1; major; virulence; protein

The malaria parasite infects red blood cells in the human host and initiates major remodelling. This involves export of a major virulence protein to the surface of the red blood cell. This research seeks to understand how the parasite exports this protein, a key determinant of disease.

疟疾寄生虫感染人类宿主的红细胞并启动主要的重塑。这涉及将主要毒力蛋白输出到红细胞表面。这项研究旨在了解寄生虫如何输出这种蛋白质，这是疾病的关键决定因素。