Trafficking and expression of PfEMP1 on the surface of P.falciparum-infected erythrocytes

PfEMP1 在恶性疟原虫感染的红细胞表面的转运和表达

• 批准号: nhmrc : 516739
• 负责人: Dr Melanie Rug
• 金额: $ 37.22万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trafficking-expression-pfemp1-infected-erythrocytes/77089
• 关键词: Trafficking; expression; PfEMP1; surface; P.falciparum

Malaria causes over 2 million deaths each year. The parasite infects human red blood cells and expresses a virulence protein on the erythrocyte surface allowing it to adhere to the microcapillaries preventing clearance through the spleen. We aim to understand how the parasite is able to express this virulence protein on the parasite-infected red blood cell surface. Identification of the proteins involved will provide potential drug targets to develop novel antimalarial compounds and strategies.

疟疾每年造成200多万人死亡。该寄生虫感染人红细胞，并在红细胞表面表达毒力蛋白，使其粘附在微毛细血管上，阻止通过脾脏清除。我们的目标是了解寄生虫是如何能够表达这种毒力蛋白的寄生虫感染的红细胞表面。鉴定所涉及的蛋白质将为开发新的抗疟化合物和策略提供潜在的药物靶点。