Identifying malaria PfEMP1 proteins that elicit antibodies associated with protection from cerebral malaria

鉴定可引发与预防脑型疟疾相关的抗体的疟疾 PfEMP1 蛋白

• 批准号: nhmrc : 1007954
• 负责人: Dr Michael Duffy
• 金额: $ 32.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-malaria-pfemp1-cerebral-malaria/109261
• 关键词: Identifying; malaria; PfEMP1; proteins; elicit

The malaria parasite changes molecules it uses to cause disease, this alters its appearance so it can escape people's immune response. However some of these molecules are similar in the parasites that cause the most severe disease. We aim to identify these similar molecules because they may make useful vaccines for protecting people from severe malaria disease.

疟疾寄生虫会改变其引起疾病的分子，从而改变其外观，从而逃避人们的免疫反应。然而，其中一些分子在引起最严重疾病的寄生虫中是相似的。我们的目标是识别这些相似的分子，因为它们可以制造有用的疫苗来保护人们免受严重的疟疾疾病的侵害。