CORE--CLINICAL GENETIC & NEUROIMAGING

核心--临床遗传学

• 批准号: 6798081
• 负责人: JOHN H GROWDON
• 金额: $ 30.46万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798081
• 关键词: Alzheimer' s disease; biomedical facility; blood chemistry; brain disorder diagnosis; brain imaging /visualization /scanning; clinical research; dementia; family genetics; genetic counseling; health education; human genetic material tag; human subject; magnetic resonance imaging; neuroimaging; neuropsychological tests; patient /disease registry; positron emission tomography; postmortem; single photon emission computed tomography

The Clinical Core of the Massachusetts ADRC is housed in the Memory Disorders Unit at the Massachusetts General Hospital. The goal of the Clinical Core is to examine, diagnosis and enroll into the ADRC Patient registry men and women from all racial and ethnic backgrounds with AD and related dementias, including frontotemporal dementia, dementia with Lewy bodies, and other parkinsonian syndromes including progressive supranuclear palsy and cortical basoganglionic degeneration, along with individuals with mild cognitive impairment who are at heightened risk to develop AD. Associated goals of the Center are to characterize the neurological, psychiatric and neuropsychological features of dementia in these patient groups and to refer these carefully evaluated patients to specific research projects funded within the ADRC, as well as to national and local research projects. To this historical mission, we have added two new components for genetics and neuroimaging. The Genetic subcore will consolidate separate elements of existing ADRC genetic programs, including the systematic collection of family history on all patients who attend the Clinical Core, genetic counseling, ascertainment of subjects for local and national genetic research projects and DNA banking and genetic analyses. The Neuroimaging subcore will standardize the collection of MR, SPECT and PET images from individuals who attend the Core, refine and apply to these images automated quantitative analytic programs developed at MGH, and facilitate collaboration with MGH investigators and other local and national ADC projects. The Clinical Core supports a wide range of research funded outside of the Clinical Core, including research projects linked to the ADRC (i.e., Project 3) as well as local and national collaborative research.

马萨诸塞州ADRC的临床核心位于马萨诸塞州综合医院的记忆障碍部门中。临床核心的目的是检查，诊断和入学，来自各种种族和种族背景的ADRC患者注册表，具有AD和相关痴呆症，包括额颞痴呆，具有Lewy身体的痴呆症以及其他帕金森尼综合症在内广告。该中心的相关目标是表征这些患者群体中痴呆症的神经，精神病和神经心理学特征，并将这些经过评估的患者推荐给ADRC中资助的特定研究项目，以及国家和地方研究项目。在这一历史使命中，我们添加了两个用于遗传学和神经影像学的新组成部分。遗传子核将巩固 现有的ADRC遗传计划，包括所有参加临床核心的患者的家族史，遗传咨询，对本地和国家遗传研究项目的受试者的确定以及DNA银行业务和遗传分析的确定。神经成像子核心将标准化来自MGH开发的自动定量分析计划的个人，完善并适用于这些图像的个人的MR，SPECT和PET图像，并促进与MGH研究人员以及其他本地和国家ADC项目的合作。临床核心支持在临床核心以外资助的广泛研究，包括与ADRC相关的研究项目（即项目3）以及 地方和国家合作研究。