SPORE in Prostate Cancer

描述（由申请人提供） 此SPORE申请是为了响应国家RFA而提交的 癌症研究所，将利用优势，在前列腺癌 研究和治疗，存在于罗伯特H。Lurie综合癌症 中心 SPORE将提供基础设施， 科学家和临床医生迅速测试新的预防方法， 人类前列腺癌的早期检测、诊断和治疗。 的 宣传教育资源的具体主题是： 1.前列腺癌的细胞和分子生物学 2.前列腺癌的预防和危险因素 3.前列腺癌的治疗和康复 4.前列腺癌患者的生活质量和预后研究 SPORE应用程序包括六个主要研究项目，三个 职业发展项目，五个试点项目和四个核心设施， 支持这项研究。 主要研究项目有：1）异黄酮， 细胞凋亡抗性（Lee），2）钙网蛋白在 前列腺癌（Wang），3）前列腺癌依赖性血管抑素的产生 4.5（Soff），4）勃起功能障碍的分子机制（McVary），5） 番茄红素对前列腺组织的影响（Gann），6）生活质量项目 前列腺癌（切拉）的银行业务。 核心设施包括： 管理、组织资源、临床和生物统计核心。 的 被选为SPORE计划一部分的调查人员来自各种各样的 从临床项目到化学工程，病理学 和化学。 为了保持研究者之间有意义的沟通，我们 将每月举行一次SPORE调查人员会议，每年举行一次务虚会， 执行委员会的月度会议。 基于基础设施 描述，我们庞大的患者群体和我们的生产力的跟踪记录， 我们认为罗伯特·H·Lurie综合癌症中心非常适合 关于SPORE计划

DESCRIPTION(provided by applicant) This SPORE application submitted in response to the RFA from the National Cancer Institute, will take advantage of the strengths in prostate cancer research and treatment that exist at the Robert H. Lurie Comprehensive Cancer Center. The SPORE will provide the infrastructure to bring together basic scientists and clinicians to rapidly test new approaches in the prevention, early detection, diagnosis and treatment of human prostate cancer. The specific themes of the SPORE are: 1. Cell and molecular biology of prostate cancer 2. Prevention and risk factors in prostate cancer development 3. Prostate cancer innovative therapeutics and rehabilitation 4. Quality of life and outcomes research in prostate cancer The SPORE application consists of six principal research projects, three career development projects, five pilot projects and four Core facilities to support the research. The principal research projects are: 1) Clusterin and resistance to apoptosis (Lee), 2) Suppressive role of calreticulin in prostate cancer (Wang), 3) Prostate cancer dependent generation of angiostatin 4.5 (Soff), 4) Molecular mechanisms of erectile dysfunction (McVary), 5) Effects of lycopene on prostatic tissue (Gann), 6) Quality of life item banking in prostate cancer (Cella). The Core facilities include: Administration, Tissue Resource, Clinical and Biostatistical Cores. The investigators selected to be part of the SPORE Program come from a variety of disciplines ranging from Clinical Programs to Chemical Engineering, Pathology and Chemistry. To maintain meaningful communication between investigators, we will have monthly meetings of SPORE investigators, an annual retreat and monthly meetings of the Executive Committee. Based on the infrastructure described, our large patient population and our track record of productivity, we believe that the Robert H. Lurie Comprehensive Cancer Center is well suited for the SPORE program.