Expression and functions of leukocyte Immunoglobulin-like Receptor (LIR)-6 and LIR-4 in inflammatory arthritis (IA).

白细胞免疫球蛋白样受体 (LIR)-6 和 LIR-4 在炎症性关节炎 (IA) 中的表达和功能。

• 批准号: nhmrc : 510236
• 负责人: A/Pr Mark Raftery
• 金额: $ 19.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expression-functions-leukocyte-arthritis-ia/82756
• 关键词: Expression; functions; leukocyte; Immunoglobulin; like

Rheumatoid arthritis (RA) that affects millions worldwide is characterised by uncontrolled activation of immune cells destroying ones own joints. The reasons for this excessive activation of cells are not known and existing treatments are limited to easing symptoms. We will study the role of new proteins named as Leucocyte Ig-like Receptors in regulating immune cell activation. Understanding mechanisms that control unwanted activation of immune cells is critical in preventing and treating RA.

风湿性关节炎（RA）影响全球数百万人，其特征是免疫细胞的不受控制的激活破坏自己的关节。这种细胞过度激活的原因尚不清楚，现有的治疗方法仅限于缓解症状。我们将研究新的蛋白质命名为白细胞免疫球蛋白样受体在调节免疫细胞活化的作用。了解控制免疫细胞不必要激活的机制对于预防和治疗RA至关重要。