Cytokines regulating airway inflammation, remodelling and hyper-reactivity in chronic asthma

细胞因子调节慢性哮喘气道炎症、重塑和高反应性

• 批准号: nhmrc : 300445
• 负责人: A/Pr Mark Raftery
• 金额: $ 21.97万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytokines-regulating-airway-chronic-asthma/95818
• 关键词: Cytokines; regulating; airway; inflammation; remodelling

This project examines a new approach to treatment of asthma, based on immunisation against the body's own chemical signals. The investigators will also be continuing studies on how twitchy airways develop in asthma, the mechanisms by which scarring of the airway walls progresses, and the signals that trigger inflammation of the airways. These studies will use a much-improved mouse model of the disease. In this experimental model, which was developed by the investigators, sensitised mice are chronically exposed to low concentrations of aerosolised egg white protein. The proposed studies will involve comparisons with animals that are immunised against certain inflammation-related molecules, as well as with mice that are genetically deficient in their ability to produce such molecules. The results of these studies may help in the development of methods for long-term suppression of the changes that develop in the airways of asthmatics.

该项目研究了一种新的治疗哮喘的方法，该方法基于对人体自身化学信号的免疫。研究人员还将继续研究哮喘中抽搐气道是如何发展的，气道壁瘢痕形成的机制以及触发气道炎症的信号。这些研究将使用一种大大改进的小鼠疾病模型。在这个由研究人员开发的实验模型中，致敏小鼠长期暴露于低浓度的雾化鸡蛋白色蛋白。拟议中的研究将涉及与对某些炎症相关分子免疫的动物进行比较，以及与基因缺陷的小鼠进行比较。这些研究的结果可能有助于开发长期抑制哮喘患者气道变化的方法。