Biochemistry and functional significance of glycosylation of apolipoprotein E

载脂蛋白E糖基化的生物化学和功能意义

• 批准号: nhmrc : 630587
• 负责人: A/Pr Mark Raftery
• 金额: $ 32.34万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biochemistry-functional-significance-apolipoprotein-e/77358
• 关键词: Biochemistry; functional; significance; glycosylation; apolipoprotein

Apolipoprotein E (apoE) is an important molecule which affects our risk of atherosclerosis- coronary disease and of Alzheimer's disease. We know that apoE's functions are very much affected by its structure. One aspect of tis structure which has been neglected is the attachment of sugar molecules . These are very likely to regulate how apoE interacts with other molecules, with cells, and is metabolised in the body and will be investigated in this project.

载脂蛋白E(ApoE)是一种重要的分子，它影响我们患动脉粥样硬化--冠状动脉疾病和阿尔茨海默病的风险。我们知道载脂蛋白E的功能受其结构的影响很大。TIS结构的一个被忽略的方面是糖分子的结合。这些都很可能调节载脂蛋白E与其他分子、细胞的相互作用，并在体内代谢，将在这个项目中进行研究。