POPULATION PHARMACOKINETICS/DYNAMICS: STATISTICAL ISSUES
群体药代动力学/动力学:统计问题
基本信息
- 批准号:6936480
- 负责人:
- 金额:$ 20.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-03-01 至 2006-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Clinical research in cancer is becoming ever more complex. Our understanding of the molecular characteristics of tumor cell growth is spawning new ideas for anticancer drug development that present challenges for the design and analysis of clinical studies to evaluate their activity. There still exists a need for better understanding of the determinants of variability in the pharmacokinetics and pharmacodynamics of commonly used anticancer drugs, as well as of these newer agents. The fact that most, if not all, anticancer agents are initially examined most closely in early phase clinical studies having relatively small sample sizes begs for methods that will combine information gathered from separate studies efficiently and coherently. Addressing these and similar issues, this application describes continuing research and development of statistical methods for the analysis and design of studies of complex data. The first specific aim concerns hierarchical modeling of correlated data with mixture priors and expands the methods to data from patients treated over multiple cycles and/or collected for multiple end points (e.g., pharmacokinetics of two or more drugs given simultaneously). The second specific aim addresses combining information from studies that generate correlated data (e.g., longitudinal profiles or assay results from multiple biopsies from the same patient) and that may have more or less in common. The application describes the development of statistical tools to carry out full Bayesian meta-analysis across studies with such correlated outcome data. Importantly, the statistical model also allows for common and study-specific components in the mixture model and for inferring in a data-dependent way the degree to which the model allows borrowing strength across studies. The third specific aim proposes optimal design rules for determining sample size, sampling times and/or numbers of samples per patient (or tumor) in the context of modeling complex biologic processes with mixture priors. The designs will allow for sequential updating of design points (e.g., sampling times) for future subjects or current subjects in subsequent cycles. The proposed work will explore the properties of these designs relative to other possible design strategies.
癌症的临床研究正变得越来越复杂。 我们对肿瘤细胞生长的分子特征的理解为抗癌药物的开发带来了新的想法,为临床研究的设计和分析提出了挑战,以评估其活性。 仍然需要更好地了解常用抗癌药物以及这些新药物的药代动力学和药效学变异性的决定因素。大多数(如果不是全部的话)抗癌剂最初在具有相对小的样本量的早期临床研究中被最密切地检查,这一事实要求将从单独的研究中有效地和连贯地收集的信息联合收割机组合的方法。 为了解决这些和类似的问题,本申请描述了用于复杂数据研究的分析和设计的统计方法的持续研究和开发。第一个具体目标涉及具有混合先验的相关数据的分层建模,并将该方法扩展到来自在多个周期内治疗和/或针对多个终点收集的患者的数据(例如,同时给予两种或多种药物的药代动力学)。第二个具体目标是将来自生成相关数据的研究的信息(例如,纵向分布或来自同一患者的多次活组织检查的测定结果),并且可能具有或多或少的共同点。 该应用程序描述了统计工具的开发,以在具有此类相关结局数据的研究中进行完整的贝叶斯荟萃分析。 重要的是,统计模型还允许混合模型中的共同和研究特定成分,并以数据依赖的方式推断模型允许跨研究借用强度的程度。第三个具体目标提出了最佳设计规则,用于确定样本量,采样时间和/或每个患者(或肿瘤)的样本数,在模拟复杂的生物过程与混合物先验的背景下。 设计将允许设计点的顺序更新(例如,采样时间)。拟议的工作将探讨这些设计相对于其他可能的设计策略的属性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GARY L ROSNER其他文献
GARY L ROSNER的其他文献
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{{ truncateString('GARY L ROSNER', 18)}}的其他基金
Training Program in Biostatistics for Cancer Research
癌症研究生物统计学培训计划
- 批准号:
6659554 - 财政年份:2003
- 资助金额:
$ 20.25万 - 项目类别:
Training Program in Biostatistics and Cancer Research
生物统计学和癌症研究培训计划
- 批准号:
7502831 - 财政年份:2003
- 资助金额:
$ 20.25万 - 项目类别:
Training Program in Biostatistics for Cancer Research
癌症研究生物统计学培训计划
- 批准号:
6932074 - 财政年份:2003
- 资助金额:
$ 20.25万 - 项目类别:
Training Program in Biostatistics for Cancer Research
癌症研究生物统计学培训计划
- 批准号:
6785431 - 财政年份:2003
- 资助金额:
$ 20.25万 - 项目类别:
Population Pharmacokinetics/Dynamic: Statistical Issues
群体药代动力学/动态:统计问题
- 批准号:
7255093 - 财政年份:1998
- 资助金额:
$ 20.25万 - 项目类别:
POPULATION PHARMACOKINETICS/DYNAMICS: STATISTICAL ISSUES
群体药代动力学/动力学:统计问题
- 批准号:
6619661 - 财政年份:1998
- 资助金额:
$ 20.25万 - 项目类别:
Population Pharmacokinetics/Dynamic: Statistical Issues
群体药代动力学/动态:统计问题
- 批准号:
7499593 - 财政年份:1998
- 资助金额:
$ 20.25万 - 项目类别:
POPULATION PHARMACOKINETICS/DYNAMICS: STATISTICAL ISSUES
群体药代动力学/动力学:统计问题
- 批准号:
6395296 - 财政年份:1998
- 资助金额:
$ 20.25万 - 项目类别:
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