Inhibition in Bipolar Disorder and ADHD

抑制双相情感障碍和多动症

• 批准号: 6998614
• 负责人: PATRICIA D WALSHAW
• 金额: $ 3.14万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998614
• 关键词: adolescence (12-20); attention deficit disorder; behavioral /social science research tag; bipolar depression; clinical research; comorbidity; developmental neurobiology; developmental psychology; electroencephalography; emotions; frontal lobe /cortex; human subject; impulsive behavior; interview; mental disorder diagnosis; model design /development; neural inhibition; predoctoral investigator; psychological models; psychological tests; questionnaires; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed study will examine the differences in inhibition in bipolar disorder and ADHD using Gray's (1981, 1987) theory of behavioral activation and inhibition (BAS and BIS) and psychophysiology. This line of research is important because it examines neurological substrates that may be useful in differentiating the neural pathways of the two disorders. The ultimate goal of this research is to build a model that may lead to the differential diagnosis of bipolar disorder and ADHD to be tested subsequently in pediatric samples. Three groups of undergraduates (bipolar, ADHD, and normal control) at Temple University will be administered a diagnostic interview for inclusion in the study. Final sample participants will be administered self-report questionnaires on BIS/BAS, impulsivity, and current mood state. A session using an electroencephalogram (EEG) will involve two computerized tasks: one measuring deficits in inhibition during a continuous performance task, the other measuring deficits in inhibition during a mixed-contingencies task involving conditions of punishment and reward. Analysis of variance techniques and follow-up tests will assess for group differences in BIS/BAS, impulsivity and inhibition, and frontal lobe asymmetries.

描述（由申请人提供）：拟议的研究将使用Gray（1981，1987）的行为激活和抑制理论（BAS和BIS）和心理生理学来检查双相情感障碍和ADHD抑制差异。这项研究很重要，因为它检查了可能在区分两种疾病的神经途径的神经系统基质。这项研究的最终目的是建立一个模型，该模型可能导致双相情感障碍和多动症的鉴别诊断，然后在小儿样本中进行测试。坦普尔大学的三组本科生（双极，多动症和正常对照）将接受诊断访谈，以纳入研究。最终的样本参与者将对BIS/BAS，冲动性和当前情绪状态的自我报告问卷进行管理。使用脑电图（EEG）的会话将涉及两个计算机化的任务：一项测量在连续绩效任务期间抑制作用的缺陷，在混合犯罪任务中，其他抑制作用的缺陷，涉及惩罚条件和奖励条件。方差技术和后续测试的分析将评估BIS/BAS，冲动性和抑制作用以及额叶不对称的群体差异。