Seasonal Plasticity of Brain and Behavior

大脑和行为的季节性可塑性

• 批准号: 6994016
• 负责人: LEAH M PYTER
• 金额: $ 2.82万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6994016
• 关键词: behavior test; gene expression; growth factor; hippocampus; histology; laboratory mouse; learning; melatonin; memory; neural plasticity; neuroendocrine system; neurogenesis; photostimulus; polymerase chain reaction; predoctoral investigator; psychobiology; seasons

DESCRIPTION (provided by applicant): Individuals of many species undergo seasonal changes in brain and behavior that evolved to optimize reproduction and survival. Photoperiod (day length) is used to determine time of year. Melatonin, secreted from the pineal gland in proportion to night-length, transduces photoperiodic information to evoke a suite of physiological, morphological, and behavioral changes that promote winter-survival. Hippocampal volume decreases in short days, a morphological change that may underlie seasonal deficits in spatial learning and memory. To evaluate the hypothesis that photoperiod mediates behavioral changes via melatonin, we will compare behaviors of deer mice exposed to long or short days or treated with melatonin. The specific aims of the proposed research are: (1) To determine whether short day-induced deficits in spatial learning and memory are mediated by melatonin. (2) To relate these photoperiod-induced deficits to structural changes in the hippocampus. (3) To determine whether photoperiod also affects non-spatial learning and memory tasks. This research will provide insights into the mechanisms of seasonal plasticity of brain and behavior

描述（由申请人提供）：许多物种的个体经历大脑和行为的季节性变化，从而进化以优化繁殖和生存。光周期（日长）用于确定一年中的时间。松果体分泌的褪黑激素与夜间长度成比例，转导光周期信息，引起一系列生理，形态和行为变化，促进冬季生存。海马体积在短时间内减少，这种形态学变化可能是空间学习和记忆的季节性缺陷的基础。为了评估光周期通过褪黑激素介导行为变化的假设，我们将比较暴露于长日照或短日照或接受褪黑激素治疗的鹿鼠的行为。本研究的具体目的是：（1）确定褪黑素是否介导了短日照引起的空间学习记忆障碍。(2)将这些光周期诱导的缺陷与海马结构的变化联系起来。(3)确定光周期是否也影响非空间学习和记忆任务。本研究将为了解季节性脑可塑性和行为的机制提供新的思路