ACTIVITY, HEALTH & QUALITY OF LIFE IN CEREBRAL PALSY

描述（由申请人提供）：超过50%的CP患者在行走技能和身体活动方面有限制。据报道，患有CP的中度至重度受损儿童的一般和身体健康状况均低于正常水平。与非残疾青少年相比，有广泛残疾青少年的生活质量较低。目前CP的治疗主要集中在治疗损伤（痉挛、力量、活动范围有限），目标是改善步行活动、健康和总体生活质量。在评估目前治疗对青年CP患者健康和生活质量的影响之前，我们必须首先描述活动水平与健康和生活质量的关系。本研究的具体目的是检验1)在控制年龄、性别、社会经济地位和当前前景的情况下，CP青少年和典型发展青少年在活动能力水平上的活动表现、自我报告的健康状况和生活质量的平均差异；2)在控制年龄、性别、社会经济地位和当前生活前景的情况下，探讨CP和TDY青年的运动水平（运动表现）与自我感知健康状况和生活质量的关系；3)在控制年龄、性别、社会经济地位和当前全球生活质量的情况下，探讨运动能力和运动表现对健康状况和生活质量的影响模型。更好地了解青年CP患者日常步行活动表现与生活体验的关系，将有助于青年CP患者行动障碍治疗的疗效研究。

DESCRIPTION (provided by applicant): More than 50% of persons with CP experience limitations in walking skills and physical activity. Moderate to severely impaired children with CP have been reported to have less than normal general and physical health. Lower QOL has been documented for adolescents with a broad spectrum of disabilities compared to non-disabled youth. Current therapies for CP focus primarily on treating impairments (spasticity, strength, limited range of motion) with the goal of improved walking activity, health and overall QOL. Before we can assess the efficacy of current treatments on the health and QOL of youth with CP, we must first describe the relationship of activity level to health and QOL. The specific aims of this study are to test the 1) mean differences in activity performance, self-reported health status and QOL by level of activity capacity in youth with CP and typically developing youth, controlling for age, gender, SES & current day outlook; 2) the associations between activity level (performance) and self-perceived health status and QOL in youth with CP and TDY, controlling for age, gender, SES and current day outlook, and 3) explore a model specifying the influence of activity capacity and activity performance on health status and quality of life controlling for age, gender, SES and current global QOL. A better understanding of the relationship of daily walking activity performance to the life experience of youth with CP will enhance the efficacy research of treatments for mobility impairments in youth with CP.