ACTIVITY, HEALTH & QUALITY OF LIFE IN CEREBRAL PALSY

描述(申请人提供)：超过50%的脑性瘫痪患者在行走技能和体力活动方面受到限制。据报道，患有中重度脑瘫的儿童总体和身体健康水平低于正常水平。与非残疾青年相比，患有广泛残疾的青少年的生活质量较低。目前CP的治疗主要集中在治疗损害(痉挛、力量、有限的运动范围)上，目的是改善步行活动、健康和总体生活质量。在评估现有治疗方法对脑性瘫痪青少年的健康和生活质量的疗效之前，我们必须首先描述活动水平与健康和生活质量的关系。本研究的具体目的是检验：1)控制年龄、性别、SES和当前日展望的CP和典型发育期青年在活动能力水平上的活动表现、自报健康状况和生活质量的平均差异；2)控制年龄、性别、SES和当前全球生活质量控制的CP和TDY青年的活动水平(表现)与自我健康状况和QOL之间的关系；3)探索活动能力和活动绩效对健康状况和生活质量的影响模型，控制年龄、性别、SES和当前全球生活质量。更好地了解日常步行活动能力与脑性瘫痪青少年生活体验的关系，将促进脑性瘫痪青少年行动能力障碍治疗的疗效研究。

DESCRIPTION (provided by applicant): More than 50% of persons with CP experience limitations in walking skills and physical activity. Moderate to severely impaired children with CP have been reported to have less than normal general and physical health. Lower QOL has been documented for adolescents with a broad spectrum of disabilities compared to non-disabled youth. Current therapies for CP focus primarily on treating impairments (spasticity, strength, limited range of motion) with the goal of improved walking activity, health and overall QOL. Before we can assess the efficacy of current treatments on the health and QOL of youth with CP, we must first describe the relationship of activity level to health and QOL. The specific aims of this study are to test the 1) mean differences in activity performance, self-reported health status and QOL by level of activity capacity in youth with CP and typically developing youth, controlling for age, gender, SES & current day outlook; 2) the associations between activity level (performance) and self-perceived health status and QOL in youth with CP and TDY, controlling for age, gender, SES and current day outlook, and 3) explore a model specifying the influence of activity capacity and activity performance on health status and quality of life controlling for age, gender, SES and current global QOL. A better understanding of the relationship of daily walking activity performance to the life experience of youth with CP will enhance the efficacy research of treatments for mobility impairments in youth with CP.