Activity and Participation in Ambulatory Cerebral Palsy

描述(申请人提供)：候选人Kristie Bjornson，博士，PT，是华盛顿大学医学院/西雅图儿童研究所儿科物理治疗师和助理教授。这一奖项将使她成为以患者为导向的干预临床研究计划的独立研究员，该计划的重点是改善脑瘫(CP)患者的活动和社会参与。这一总体目标将通过一项为期五年的培训、指导和研究计划来实现，具体目标如下：1)在日常生活的背景下，培养测量身体成分、能量消耗、步行和体力活动表现以及社会参与的知识和技能。2)使用技能进行横断面描述性研究，测试ICF组件之间的关系。3)提高对矫形处方和生物力学的认识。4)在横断面矫形介入研究中发展方法学和试点。5)扩大临床试验方法、研究管理/领导、拨款发展和学术写作方面的知识。候选人的赞助人是一位公认的儿科研究员和职业导师，而她的联合赞助人和咨询委员会代表了与研究人群和职业发展计划直接相关的临床和研究专业知识。该研究计划首先集中于确定活动、参与(ICF)和身体成分的关系，这是一项对患有脑瘫的儿童进行的描述性横断面研究。ICF在不同层面的结果需要澄清，以便ICF成为临床研究和实践的有用框架。其次，ICF组件的关系将在实心踝足矫形器(SAFO)的随机交叉临床试验中进行测试，该临床试验采用新的动态加速度量仪测量脑瘫儿童的日常活动/体力活动表现和社会参与情况。目前还没有公布的数据定义Safo对身体和步行活动、表现和参与日常生活的影响。这些信息将有助于为CP患者制定终身矫形器管理算法。 公共卫生相关性：PI将探索脑瘫儿童在运动测试中的身体行为与他们在日常生活中“实际”行为之间的联系。该项目还将测试脚踝支架是否有助于脑瘫儿童在他们想做的时候做他们想做的事情。这些信息将被用来为脑瘫患者制定终生脚踝支撑指南。

DESCRIPTION (provided by applicant): The candidate, Kristie Bjornson, PhD, PT, is a pediatric physical therapist and Assistant Professor of Pediatrics, University of Washington School of Medicine/Seattle Children's Research Institute. This award will establish her as an independent investigator in a patient-oriented clinical research program of interventions focused on improving the activity and social participation of persons with cerebral palsy (CP). This overarching goal will be accomplished through a five-year program of training, mentoring and research with the following specific objectives: 1) Develop knowledge and skill in the measurement of body composition, energy expenditure, ambulatory and physical activity performance and social participation within the context of daily life. 2) Employ skills in a cross-sectional descriptive study testing the relationship of the ICF components. 3) Enhance understanding of orthotic prescription and biomechanics. 4) Develop methodology and pilot within a cross-sectional orthotic intervention study. 5) Expand knowledge of clinical trials methods, study management/leadership, grant development and scholarly writing. The candidate's sponsor is an established pediatric researcher and career mentor, while her co-sponsor and advisory committee represent clinical and research expertise directly related to the study population and career development plan. The research plan focuses first on defining the relationships of activity, participation (ICF) and body composition in a descriptive cross-sectional study of ambulatory children with CP. The extent outcomes at various levels of the ICF relate requires clarification in order for the ICF to be a useful framework for clinical research and practice. Secondarily, the ICF component relationships will be tested within a randomized cross-over clinical trial of solid ankle foot orthoses (SAFO) on daily ambulatory/physical activity performance and social participation on ambulatory children with cerebral palsy with novel ambulatory accelerometry measures. There are no published data defining the impact of SAFO on physical and ambulatory activity performance and participation in day to day life. This information will facilitate the development of a life span orthotic management algorithm for ambulatory persons with CP. Public Health Relevance: The PIs will explore the connection between what a child with cerebral palsy does physically during motor testing to what they 'actually' do during their day to day lives. The project will also test whether ankle braces help children with cerebral palsy do what they want to do when they want to do it. This information will be used to develop ankle bracing guidelines for persons with, cerebral palsy across the life span.