Magnetic delivery of anit-cancer magnetosomes using MRI

使用 MRI 磁传递抗癌磁小体

• 批准号: 2608790
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2608790
• 关键词: Magnetic; delivery; anit; cancer; magnetosomes

Background: Oncolytic virotherapy to destroy cancer has fast gained acceptance as acancer treatment modality with the recent FDA approval for Amgen's T-VEC (an oncolyticHSV) in melanoma. However, following intravenous administration oncolytic viruses (OV) aremassively compromised by host defense mechanisms limiting applicability to accessibletumours where injection of OV directly into the tumour is necessary. MRI scanners offer newopportunities to magnetically guide anticancer therapies accurately to tumours. Wehypothesise that such precise delivery of OVs using MRT will massively improve therapeuticefficacy following injection into the blood stream, whilst preventing unwanted immune attackof the virus.The Aims of this project are (1) To use the powerful-pulsed magnetic field gradient of an MRIscanner to deliver magnetosome-OV complexes (Mag-OV) to mice with metastatic tumours.The MRI scanner will also be used also be used to track therapy after administration bygenerating longitudinal images of the treated tissue (2) To use mathematical models to (i)identify the key physical processes in the targeting protocol, (ii) predict efficacy of MRT inother murine cancer models (iii) to scale it up to application in humans.

背景资料：随着最近FDA批准安进公司的T-VEC（一种溶瘤HSV）用于黑色素瘤，溶瘤病毒疗法作为一种癌症治疗方式迅速获得认可。然而，静脉给药后，溶瘤病毒（OV）受到宿主防御机制的严重损害，限制了OV直接注射到肿瘤中是必要的可接近肿瘤的适用性。MRI扫描仪提供了新的机会，以磁性引导抗癌疗法准确地治疗肿瘤。我们假设，使用MRT精确递送OV将大大提高注射到血流中后的治疗效果，本课题的主要目的是：（1）利用磁共振扫描仪的强脉冲磁场梯度传递磁小体-OV复合物（Mag-OV），MRI扫描仪也将用于在给药后通过产生治疗组织的纵向图像来跟踪治疗（2）使用数学模型来（i）确定靶向方案中的关键物理过程，（ii）预测MRT在其他鼠癌症模型中的疗效，（iii）将其扩大到在人类中的应用。