Magnetic delivery of anit-cancer magnetosomes using MRI

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Background: Oncolytic virotherapy to destroy cancer has fast gained acceptance as acancer treatment modality with the recent FDA approval for Amgen's T-VEC (an oncolyticHSV) in melanoma. However, following intravenous administration oncolytic viruses (OV) aremassively compromised by host defense mechanisms limiting applicability to accessibletumours where injection of OV directly into the tumour is necessary. MRI scanners offer newopportunities to magnetically guide anticancer therapies accurately to tumours. Wehypothesise that such precise delivery of OVs using MRT will massively improve therapeuticefficacy following injection into the blood stream, whilst preventing unwanted immune attackof the virus.The Aims of this project are (1) To use the powerful-pulsed magnetic field gradient of an MRIscanner to deliver magnetosome-OV complexes (Mag-OV) to mice with metastatic tumours.The MRI scanner will also be used also be used to track therapy after administration bygenerating longitudinal images of the treated tissue (2) To use mathematical models to (i)identify the key physical processes in the targeting protocol, (ii) predict efficacy of MRT inother murine cancer models (iii) to scale it up to application in humans.