Validation of New Diagnostic Technologies for Dental Caries

新型龋齿诊断技术的验证

• 批准号: 7172842
• 负责人: JAMES STERN WEFEL
• 金额: $ 72.23万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7172842
• 关键词: children; clinical research; decision making; diagnosis; early diagnosis; fluorescence; gold; lighting; measurement; model; tooth; tooth surface

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries in children and adults due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this dramatic improvement, dental caries continues to be the most prevalent dental disease. The early detection and monitoring of tooth surface demineralization is a critical step in reducing the prevalence of dental caries. The identification and validation and then use of new technologies should increase the efficiency of caries clinical trials and reduce their cost. One of the major goals of this grant is to validate new and refined technologies for the clinical assessment of tooth surface demineralization. This proposal will concentrate on using Quantitative light-induced fluorescence (QLF) alone, in combination with Red Fluorescence, and with the incorporation of a new hand piece and drying procedure. These technologies are designed to detect early signs of demineralization and should be able to monitor lesion progression and/or regression. This grant will also use the recently developed International Caries Detection and Assessment System (ICDAS) for the visual exam and record both cavitated and non-cavitated lesions. This grant will take advantage of the working relationship developed between three established teams of Cariologists during their previous program project grant and the experiences gained from that endeavor. As such the aims of this grant will include both in vitro studies (Iowa) to monitor demin/remin as well as in vivo studies (Indian and Texas) to validate monitoring of demin/remin clinically. The data generated will then be used in the fourth specific aim to develop a guide for clinical decision making that include the QLF measurements and the ICDAS visual exam. The clinical validation studies will use an Orthodontic population for permanent caries (SA 3) and a child population for deciduous caries (SA 2). The "exfoliated tooth model histopathology" will be used with the studies on the deciduous dentition as the gold standard for validation. The clinical data will be paired with the PLM for validity measurements and analyzed by the biostatisticians.

描述（由申请人提供）：在过去的40年中，由于在公共卫生计划中广泛使用氟化物，例如公共水氟化，牙科实践和口腔卫生产品，儿童和成人龋齿的患病率显着下降。尽管有了这种巨大的改善，但龋齿仍然是最普遍的牙齿疾病。牙齿表面脱矿的早期检测和监测是降低龋齿患病率的关键步骤。识别和验证，然后使用新技术应提高龋齿临床试验的效率并降低其成本。 该赠款的主要目标之一是验证新的和精致的技术，以评估牙齿表面脱矿化的临床评估。该建议将仅使用定量光诱导的荧光（QLF），并结合红色荧光，并结合新手件和干燥程序。这些技术旨在检测脱矿物的早期迹象，并应能够监测病变的进展和/或回归。该赠款还将使用最近开发的国际龋齿检测和评估系统（ICDAS）进行视觉检查，并记录洞穴和未储存的病变。 这笔赠款将利用三个既定的商家团队在其上一项计划项目赠款中建立的工作关系以及从该努力中获得的经验。因此，这笔赠款的目的将包括体外研究（爱荷华州）以监测粉末/雷敏以及体内研究（印度和德克萨斯州），以验证临床上对Demin/Remin的监测。然后，生成的数据将用于第四个特定目的，以制定包括QLF测量和ICDAS视觉检查在内的临床决策指南。临床验证研究将使用正畸种群用于永久性龋齿（SA 3）和儿童种群用于乳节龋（SA 2）。 “去角质牙齿模型组织病理学”将与落叶牙列的研究一起用作验证的黄金标准。临床数据将与PLM配对以进行有效性测量，并由生物统计学家进行分析。