Validation of New Diagnostic Technologies for Dental Caries

描述（由申请人提供）：在过去 40 年中，由于公共健康项目（例如公共水氟化、牙科诊所和口腔卫生产品）中氟化物的广泛使用，儿童和成人的龋齿患病率显着下降。尽管有了如此显着的改善，龋齿仍然是最普遍的牙科疾病。早期检测和监测牙齿表面脱矿是减少龋齿患病率的关键一步。新技术的识别、验证和使用应该提高龋齿临床试验的效率并降低其成本。 这笔赠款的主要目标之一是验证用于牙齿表面脱矿临床评估的新技术和改进技术。该提案将集中于单独使用定量光诱导荧光（QLF），与红色荧光相结合，并结合新的手持件和干燥程序。这些技术旨在检测脱矿质的早期迹象，并且应该能够监测病变进展和/或消退。这笔赠款还将使用最近开发的国际龋齿检测和评估系统（ICDAS）进行视觉检查并记录空洞和非空洞病变。 这笔赠款将利用三个已建立的龋病学家团队在之前的计划项目赠款期间建立的工作关系以及从该努力中获得的经验。因此，这笔赠款的目的将包括监测 demin/remin 的体外研究（爱荷华州）以及验证 demin/remin 临床监测的体内研究（印度和德克萨斯州）。生成的数据将用于第四个具体目标，即制定临床决策指南，其中包括 QLF 测量和 ICDAS 视觉检查。临床验证研究将使用正畸人群治疗永久性龋齿 (SA 3) 和儿童人群治疗乳牙龋齿 (SA 2)。 “脱落牙模型组织病理学”将与乳牙列研究一起作为验证的金标准。临床数据将与 PLM 配对进行有效性测量并由生物统计学家进行分析。

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries in children and adults due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this dramatic improvement, dental caries continues to be the most prevalent dental disease. The early detection and monitoring of tooth surface demineralization is a critical step in reducing the prevalence of dental caries. The identification and validation and then use of new technologies should increase the efficiency of caries clinical trials and reduce their cost. One of the major goals of this grant is to validate new and refined technologies for the clinical assessment of tooth surface demineralization. This proposal will concentrate on using Quantitative light-induced fluorescence (QLF) alone, in combination with Red Fluorescence, and with the incorporation of a new hand piece and drying procedure. These technologies are designed to detect early signs of demineralization and should be able to monitor lesion progression and/or regression. This grant will also use the recently developed International Caries Detection and Assessment System (ICDAS) for the visual exam and record both cavitated and non-cavitated lesions. This grant will take advantage of the working relationship developed between three established teams of Cariologists during their previous program project grant and the experiences gained from that endeavor. As such the aims of this grant will include both in vitro studies (Iowa) to monitor demin/remin as well as in vivo studies (Indian and Texas) to validate monitoring of demin/remin clinically. The data generated will then be used in the fourth specific aim to develop a guide for clinical decision making that include the QLF measurements and the ICDAS visual exam. The clinical validation studies will use an Orthodontic population for permanent caries (SA 3) and a child population for deciduous caries (SA 2). The "exfoliated tooth model histopathology" will be used with the studies on the deciduous dentition as the gold standard for validation. The clinical data will be paired with the PLM for validity measurements and analyzed by the biostatisticians.