Validation of New Diagnostic Technologies for Dental Caries

描述(申请人提供)：在过去的40年里，由于氟化物在公共卫生项目中的广泛使用，如公共用水加氟、牙科实践和口腔卫生产品，儿童和成人的龋齿患病率显著下降。尽管有了显著的改善，龋齿仍然是最常见的牙病。牙面脱矿的早期发现和监测是降低龋患率的关键步骤。新技术的识别和验证以及新技术的使用将提高龋病临床试验的效率并降低其成本。 这笔赠款的主要目标之一是验证用于牙齿表面脱矿临床评估的新的和改进的技术。这项提议将集中于单独使用定量光诱导荧光(QLF)，与红色荧光相结合，并结合新的手机和干燥程序。这些技术旨在检测脱矿的早期迹象，并应能够监测病变进展和/或退化。这笔赠款还将使用最近开发的国际龋齿检测和评估系统(ICDAS)进行肉眼检查，并记录空洞和非空洞病变。 这笔赠款将利用三个已建立的龋病学家团队在之前的计划项目赠款期间建立的工作关系和从这一努力中获得的经验。因此，这笔赠款的目的将包括监测DEMIN/REMIN的体外研究(爱荷华州)以及临床验证DEMIN/REMIN监测的体内研究(印度和德克萨斯州)。然后，生成的数据将用于第四个特定目标，以制定临床决策指南，其中包括QLF测量和ICDAS视觉检查。临床验证研究将使用正畸人群(SA3)和儿童人群(SA2)来治疗乳牙龋齿。“剥落牙模型组织病理学”将被用于乳牙研究作为验证的金标准。临床数据将与PLM配对进行有效性测量，并由生物统计学家进行分析。

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries in children and adults due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this dramatic improvement, dental caries continues to be the most prevalent dental disease. The early detection and monitoring of tooth surface demineralization is a critical step in reducing the prevalence of dental caries. The identification and validation and then use of new technologies should increase the efficiency of caries clinical trials and reduce their cost. One of the major goals of this grant is to validate new and refined technologies for the clinical assessment of tooth surface demineralization. This proposal will concentrate on using Quantitative light-induced fluorescence (QLF) alone, in combination with Red Fluorescence, and with the incorporation of a new hand piece and drying procedure. These technologies are designed to detect early signs of demineralization and should be able to monitor lesion progression and/or regression. This grant will also use the recently developed International Caries Detection and Assessment System (ICDAS) for the visual exam and record both cavitated and non-cavitated lesions. This grant will take advantage of the working relationship developed between three established teams of Cariologists during their previous program project grant and the experiences gained from that endeavor. As such the aims of this grant will include both in vitro studies (Iowa) to monitor demin/remin as well as in vivo studies (Indian and Texas) to validate monitoring of demin/remin clinically. The data generated will then be used in the fourth specific aim to develop a guide for clinical decision making that include the QLF measurements and the ICDAS visual exam. The clinical validation studies will use an Orthodontic population for permanent caries (SA 3) and a child population for deciduous caries (SA 2). The "exfoliated tooth model histopathology" will be used with the studies on the deciduous dentition as the gold standard for validation. The clinical data will be paired with the PLM for validity measurements and analyzed by the biostatisticians.