Validation of New Diagnostic Technologies for Dental Caries

描述（由申请人提供）：在过去的40年中，由于氟化物在公共卫生项目中的广泛使用，如公共饮水氟化、牙科实践和口腔卫生产品，儿童和成人龋齿的患病率显著下降。尽管有了这种显著的改善，但龋齿仍然是最普遍的牙科疾病。早期发现和监测牙齿表面脱矿是降低龋齿患病率的关键步骤。识别和验证，然后使用新的技术应提高效率的龋齿临床试验，并降低其成本。 该基金的主要目标之一是验证用于牙齿表面脱矿的临床评估的新技术和改进技术。该提案将集中于单独使用定量光诱导荧光（QLF），与红色荧光结合使用，并结合新的手柄和干燥程序。这些技术旨在检测脱矿的早期迹象，并应能够监测病变进展和/或消退。这项赠款还将使用最近开发的国际龋齿检测和评估系统（ICDAS）进行视力检查，并记录有空洞和无空洞的病变。 这笔赠款将利用在他们以前的计划项目赠款和从这一奋进中获得的经验，三个已建立的团队之间的工作关系。因此，该赠款的目的将包括体外研究（爱荷华州），以监测demin/remin以及体内研究（印度和得克萨斯州），以验证demin/remin的临床监测。然后，生成的数据将用于第四个具体目标，以制定临床决策指南，包括QLF测量和ICDAS目视检查。临床验证研究将使用正畸人群进行永久性龋齿（SA 3）和儿童人群进行乳牙龋齿（SA 2）。乳牙列的研究将使用“脱落牙模型组织病理学”作为验证的金标准。临床数据将与PLM配对进行有效性测量，并由生物统计学家进行分析。

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries in children and adults due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this dramatic improvement, dental caries continues to be the most prevalent dental disease. The early detection and monitoring of tooth surface demineralization is a critical step in reducing the prevalence of dental caries. The identification and validation and then use of new technologies should increase the efficiency of caries clinical trials and reduce their cost. One of the major goals of this grant is to validate new and refined technologies for the clinical assessment of tooth surface demineralization. This proposal will concentrate on using Quantitative light-induced fluorescence (QLF) alone, in combination with Red Fluorescence, and with the incorporation of a new hand piece and drying procedure. These technologies are designed to detect early signs of demineralization and should be able to monitor lesion progression and/or regression. This grant will also use the recently developed International Caries Detection and Assessment System (ICDAS) for the visual exam and record both cavitated and non-cavitated lesions. This grant will take advantage of the working relationship developed between three established teams of Cariologists during their previous program project grant and the experiences gained from that endeavor. As such the aims of this grant will include both in vitro studies (Iowa) to monitor demin/remin as well as in vivo studies (Indian and Texas) to validate monitoring of demin/remin clinically. The data generated will then be used in the fourth specific aim to develop a guide for clinical decision making that include the QLF measurements and the ICDAS visual exam. The clinical validation studies will use an Orthodontic population for permanent caries (SA 3) and a child population for deciduous caries (SA 2). The "exfoliated tooth model histopathology" will be used with the studies on the deciduous dentition as the gold standard for validation. The clinical data will be paired with the PLM for validity measurements and analyzed by the biostatisticians.